HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	31753913, 23602568
Identification Methods	affinity chromatography technology, enzymatic study, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 688 Hs			1 726
+	Hs
		1071489 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		ZMY11_HUMAN (3-446): 1.03e-44: 171: 9.63
+	Hs
		942618 SRPK2_HUMAN (12-688): 3.2e-128: 397: 95.66		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		998998 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		244822 SRPK1_HUMAN (27-688): 1.57e-125: 388: 53.22		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		625449 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		ZMY11_HUMAN (3-446): 1.03e-44: 171: 9.63
+	Hs
		625393 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		625533 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		KAT2A_HUMAN (267-414): 1.15e-33: 140: 28.86
+	Hs
		625534 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Mm
		101422 KS6A3_MOUSE (2-362): 2.34e-78: 266: 13.83		F8VPR5_MOUSE (19-143): 9.58e-32: 135: 30.23
+	Hs
		270406 KS6A5_HUMAN (3-343): 1.04e-72: 252: 14.52		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		243949 CDK2_HUMAN (378-687): 1.93e-91: 288: 17.14		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Sp
		737010 DSK1_SCHPO (437-686): 7.4e-74: 250: 44.40		YK82_SCHPO (29-148): 6.59e-30: 128: 33.61
+	Hs
		999248 DYR1B_HUMAN (502-686): 8.03e-59: 211: 28.02		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		999150 CDK12_HUMAN (291-687): 5.8e-54: 203: 13.17		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Sc
		419948 SNF1_YEAST (380-687): 4.14e-43: 166: 11.90		GCN5_YEAST (284-417): 7.13e-37: 145: 31.88
+	Hs
		244418 CDK13_HUMAN (373-687): 1.6e-54: 204: 15.85		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		245029 CDK12_HUMAN (291-687): 5.8e-54: 203: 13.17		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Sc
		419974 SNF1_YEAST (380-687): 4.14e-43: 166: 11.90		BDF2_YEAST (250-500): 3e-24: 110: 20.32