HitPredict

Interactor 1: CRADD (P78560)
Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain)
Gene: CRADD

Interactor 2: PIDD1 (Q9HB75)
p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]
Gene: PIDD1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

The method score is based on:

Property	Details
Experiments	15073321, 22854598, 16360037, 21415862, 23049853, 27773430, 17159900, 16652156
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CARD~Death, Death~Death, Death~ZU5
Common GO terms	GO:0005634 - nucleus GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006974 - DNA damage response and 4 others more... GO:0006977 - DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0043065 - positive regulation of apoptotic process GO:1905369 - endopeptidase complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	199
Hs

1	910

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024