HitPredict

Interactor 1: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 164 Hs			1 2752
+	Hs
		1084451 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		992995 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1028876 SRSF5_HUMAN (10-112): 2.09e-24: 97: 44.34		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		267100 SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		516749 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		952089 SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		516546 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		PRC2B_HUMAN (640-2750): 5.74e-64: 245: 9.36
+	Hs
		853964 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		MINT_HUMAN (709-2695): 5.55e-37: 157: 9.30
+	Hs
		1084300 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		PPRC1_HUMAN (318-1646): 1.46e-15: 85.9: 9.67
+	Hs
		1031405 PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		516609 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		1084386 SRSF7_HUMAN (9-106): 1.02e-30: 112: 67.35		DIDO1_HUMAN (13-1216): 9.01e-11: 70.1: 10.22
+	Hs
		853922 NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14		PPRC1_HUMAN (318-1646): 1.46e-15: 85.9: 9.67
+	Hs
		820908 PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		516406 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		992912 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		DIDO1_HUMAN (13-1216): 9.01e-11: 70.1: 10.22
+	Hs
		993011 SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65		PRC2C_HUMAN (1360-2752): 9.55e-11: 70.1: 9.11
+	Hs
		516766 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		PRC2C_HUMAN (1360-2752): 9.55e-11: 70.1: 9.11
+	Hs
		516595 PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77		KMT2C_HUMAN (1760-2747): 2.06e-09: 65.9: 9.01
+	Hs
		965152 PABP3_HUMAN (1-91): 6.48e-19: 84.6: 23.71		ANK2_HUMAN (1488-2676): 2.26e-09: 65.6: 13.23