HitPredict

Interactor 1: RAC3 (P60764)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: GDIR2 (Q61599)
Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (D4) (Rho-GDI beta)
Gene: Arhgdib

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0003924 - GTPase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 200
+	Hs
		912546 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Mm
		988911 RAC1_MOUSE (1-192): 2.11e-85: 251: 92.71		GDIR1_MOUSE (1-200): 4.27e-105: 302: 64.71
+	Hs
		580945 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Hs
		912535 RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Mm
		953794 RAC3_MOUSE (1-192): 5.48e-80: 238: 100.00		GDIR1_MOUSE (1-200): 4.27e-105: 302: 64.71
+	Hs
		912629 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		GDIR2_HUMAN (1-200): 4.43e-99: 287: 86.57
+	Hs
		912548 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Hs
		912536 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Hs
		988652 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		GDIR3_HUMAN (1-200): 1.77e-97: 283: 56.22
+	Hs
		912539 RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Rn
		962876 RHOA_RAT (5-192): 4.11e-77: 230: 54.79		GDIR1_RAT (1-200): 4.27e-105: 302: 64.71
+	Hs
		580946 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		GDIR2_HUMAN (1-200): 4.43e-99: 287: 86.57
+	Hs
		912625 RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00		GDIR2_HUMAN (1-200): 4.43e-99: 287: 86.57
+	Hs
		912630 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		GDIR2_HUMAN (1-200): 4.43e-99: 287: 86.57
+	Hs
		1015716 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		GDIR3_HUMAN (1-200): 1.77e-97: 283: 56.22
+	Hs
		955520 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		GDIR3_HUMAN (1-200): 1.77e-97: 283: 56.22
+	Hs
		962421 RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32		GDIR3_HUMAN (1-200): 1.77e-97: 283: 56.22
+	At
		1182536 RAC5_ARATH (4-177): 1.21e-78: 234: 64.37		GDIR_ARATH (1-198): 5.12e-88: 260: 38.00
+	Ce
		1041911 RAC1_CAEEL (1-192): 2.91e-83: 246: 81.25		GDIR_CAEEL (12-197): 1.56e-74: 224: 39.04
+	Cl
		47461 RAC1_CANLF (1-192): 2.11e-85: 251: 92.71		A0A8I3N6C6_CANLF (1-200): 2.18e-70: 213: 47.55