HitPredict

Interactor 1: RAC3 (P60764)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: GDIR1 (Q99PT1)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (GDI-1) (Rho-GDI alpha)
Gene: Arhgdia

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.80	0.528

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 204
+	Hs
		912546 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		GDIR1_HUMAN (1-204): 9.38e-117: 332: 97.06
+	Mm
		988911 RAC1_MOUSE (1-192): 2.11e-85: 251: 92.71		GDIR1_MOUSE (1-204): 9.48e-117: 332: 100.00
+	Hs
		580945 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		GDIR1_HUMAN (1-204): 9.38e-117: 332: 97.06
+	Hs
		912535 RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00		GDIR1_HUMAN (1-204): 9.38e-117: 332: 97.06
+	Hs
		912548 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		GDIR1_HUMAN (1-204): 9.38e-117: 332: 97.06
+	Hs
		912536 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		GDIR1_HUMAN (1-204): 9.38e-117: 332: 97.06
+	Rn
		962876 RHOA_RAT (5-192): 4.11e-77: 230: 54.79		GDIR1_RAT (1-204): 9.48e-117: 332: 100.00
+	Hs
		912539 RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32		GDIR1_HUMAN (1-204): 9.38e-117: 332: 97.06
+	Hs
		912629 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		GDIR2_HUMAN (23-204): 7.76e-97: 281: 71.98
+	Hs
		988652 RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71		GDIR3_HUMAN (15-204): 4.08e-96: 280: 60.53
+	Hs
		580946 RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54		GDIR2_HUMAN (23-204): 7.76e-97: 281: 71.98
+	Mm
		953791 RAC3_MOUSE (1-192): 5.48e-80: 238: 100.00		GDIR2_MOUSE (13-204): 2.04e-98: 285: 67.71
+	Hs
		912625 RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00		GDIR2_HUMAN (23-204): 7.76e-97: 281: 71.98
+	Hs
		912630 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		GDIR2_HUMAN (23-204): 7.76e-97: 281: 71.98
+	Hs
		1015716 RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79		GDIR3_HUMAN (15-204): 4.08e-96: 280: 60.53
+	Hs
		955520 CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75		GDIR3_HUMAN (15-204): 4.08e-96: 280: 60.53
+	Hs
		962421 RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32		GDIR3_HUMAN (15-204): 4.08e-96: 280: 60.53
+	At
		1182536 RAC5_ARATH (4-177): 1.21e-78: 234: 64.37		GDIR_ARATH (2-202): 3.94e-89: 263: 37.86
+	Cl
		47461 RAC1_CANLF (1-192): 2.11e-85: 251: 92.71		A0A8I3N6C6_CANLF (1-204): 5.15e-81: 239: 77.45
+	Ce
		1041911 RAC1_CAEEL (1-192): 2.91e-83: 246: 81.25		GDIR_CAEEL (20-201): 3.61e-75: 226: 39.34