HitPredict

Interactor 1: GDIR1 (P52565)
Rho GDP-dissociation inhibitor 1 (Rho GDI 1) (Rho-GDI alpha)
Gene: ARHGDIA

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.806

Property	Details
Experiments	35271311, 21900206
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 204 Hs			1 192
+	Hs
		912546 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71
+	Mm
		988911 GDIR1_MOUSE (1-204): 6.29e-117: 332: 97.06		RAC1_MOUSE (1-192): 2.11e-85: 251: 92.71
+	Hs
		580945 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54
+	Mm
		953794 GDIR1_MOUSE (1-204): 6.29e-117: 332: 97.06		RAC3_MOUSE (1-192): 5.48e-80: 238: 100.00
+	Hs
		912548 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79
+	Hs
		912536 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75
+	Rn
		962876 GDIR1_RAT (1-204): 6.29e-117: 332: 97.06		RHOA_RAT (5-192): 4.11e-77: 230: 54.79
+	Hs
		912539 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32
+	Hs
		466166 GDIR1_HUMAN (1-204): 5.05e-117: 332: 100.00		RHOC_HUMAN (5-192): 2.47e-74: 223: 54.79
+	Hs
		912629 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71
+	Hs
		988652 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		RAC1_HUMAN (1-192): 2.11e-85: 251: 92.71
+	Hs
		580946 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC2_HUMAN (1-192): 9.15e-82: 242: 88.54
+	Mm
		953791 GDIR2_MOUSE (13-204): 1.26e-98: 285: 68.75		RAC3_MOUSE (1-192): 5.48e-80: 238: 100.00
+	Hs
		912625 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RAC3_HUMAN (1-192): 5.48e-80: 238: 100.00
+	Hs
		912630 GDIR2_HUMAN (23-204): 1.22e-96: 281: 72.53		RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79
+	Hs
		1015716 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		RHOG_HUMAN (1-192): 1.04e-78: 234: 69.79
+	Hs
		955520 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		CDC42_HUMAN (1-192): 1.05e-77: 231: 68.75
+	Hs
		962421 GDIR3_HUMAN (15-204): 5.89e-96: 280: 61.05		RHOA_HUMAN (5-192): 9.22e-77: 229: 55.32
+	At
		1182536 GDIR_ARATH (2-202): 4.37e-89: 263: 37.86		RAC5_ARATH (4-177): 1.21e-78: 234: 64.37
+	At
		1182495 GDIR_ARATH (2-202): 4.37e-89: 263: 37.86		RAC3_ARATH (2-192): 1.05e-72: 219: 60.20