Interactor 1: SMAD4 (P97471)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4)
Gene: SMAD4

Interactor 2: SKI (Q60698)
Ski oncogene (Proto-oncogene c-Ski)
Gene: SKI

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.44 1.00 0.665

The method score is based on:

Property Details
Experiments 29072299
Identification Methods anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains MH2~c-SKI_SMAD_bind
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003682 - chromatin binding
GO:0005634 - nucleus
and 8 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 551
Mm

1 725
+ Hs
+ Hs
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+ Hs
+ Hs
+ Gg
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+ Gg
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+ Hs
+ Dm
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+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024