HitPredict

Interactor 1: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 582 Hs			1 435
+	Hs
		666154 SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		1287523 GULP1_HUMAN (130-442): 1.9e-44: 161: 20.06		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Ce
		283750 CED6_CAEEL (93-497): 1.43e-45: 169: 17.48		AP2M_CAEEL (1-435): 3.73e-172: 491: 80.95
+	Hs
		275599 BCAR3_HUMAN (398-580): 2.03e-33: 138: 20.39		AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85
+	Hs
		924775 GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00
+	Hs
		970753 APBA1_HUMAN (2-329): 9.58e-49: 183: 15.63		AP3M1_HUMAN (1-434): 1.4e-123: 366: 24.66
+	Mm
		1206658 ANS1B_MOUSE (26-366): 5.11e-50: 188: 14.01		AP3M2_MOUSE (1-434): 4.8e-118: 352: 24.89
+	Hs
		411901 LCK_HUMAN (321-582): 1.49e-36: 144: 14.60		AP3M1_HUMAN (1-434): 1.4e-123: 366: 24.66