HitPredict

Interactor 1: SHC1 (P98083)
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: SHIP1 (Q9ES52)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
Gene: Inpp5d

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.944

Property	Details
Experiments	9393882, 8723348, 20697350, 15470047, 10068665, 10748054
Identification Methods	affinity chromatography technology, far western blotting, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 579 Mm			1 1191
+	Hs
		666147 SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Rn
		956852 SHC1_RAT (111-579): 3.86e-152: 447: 98.08		SHIP1_RAT (1-1191): 0: 925: 96.56
+	Mm
		957241 SHC1_MOUSE (1-579): 0: 536: 100.00		SHIP2_MOUSE (5-1109): 0: 675: 38.98
+	Hs
		176390 SHC1_HUMAN (1-579): 5.04e-179: 520: 94.17		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Mm
		403460 SRC_MOUSE (334-570): 3.59e-44: 166: 16.87		SHIP1_MOUSE (1-1191): 0: 930: 100.00
+	Hs
		557759 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SHIP1_HUMAN (4-1187): 0: 868: 87.21
+	Hs
		145960 SH2B2_HUMAN (339-577): 5.95e-43: 164: 21.14		SHIP2_HUMAN (4-1109): 0: 676: 39.83
+	Mm
		1159871 SH2B2_MOUSE (339-577): 1.01e-36: 146: 21.14		SHIP2_MOUSE (5-1109): 0: 675: 38.98
+	Hs
		166030 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		166024 FYN_HUMAN (367-579): 2.26e-40: 156: 18.86		SYNJ2_HUMAN (275-1189): 8.74e-162: 522: 18.03
+	Hs
		522919 SRC_HUMAN (334-570): 7.45e-44: 166: 16.87		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Hs
		412137 FYN_HUMAN (367-579): 2.26e-40: 156: 18.86		OCRL_HUMAN (252-815): 1.97e-151: 479: 23.16
+	Ce
		105280 Q95PW9_CAEEL (386-577): 2.49e-35: 139: 20.10		SYNJ_CAEEL (257-1001): 1.46e-140: 456: 17.44
+	Hs
		243126 SRC_HUMAN (334-570): 7.45e-44: 166: 16.87		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		155829 SRC_HUMAN (334-570): 7.45e-44: 166: 16.87		SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33
+	Mm
		292397 FYN_MOUSE (367-579): 2.26e-40: 156: 18.86		SH21A_MOUSE (10-104): 1.81e-21: 93.2: 46.32
+	Hs
		243127 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		243121 FYN_HUMAN (367-579): 2.26e-40: 156: 18.86		SH21A_HUMAN (10-104): 2.15e-20: 90.1: 44.21
+	Hs
		155835 BLK_HUMAN (362-577): 2.17e-40: 155: 18.14		SH21B_HUMAN (8-104): 3.51e-20: 89.7: 44.33
+	Hs
		203208 NCK1_HUMAN (360-571): 3.06e-42: 157: 19.37		SYNJ1_HUMAN (960-1191): 1.57e-11: 71.2: 13.62