HitPredict

Interactor 1: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Interactor 2: NET5 (Q8WTR8)
Netrin-5 (Netrin-1-like protein)
Gene: NTN5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Laminin_EGF~Ldl_recept_b
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 4655 Hs			1 489
+	Hs
		1259455 SORL_HUMAN (166-470): 5.79e-19: 98: 16.82		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		351091 LDLR_HUMAN (927-1187): 1.96e-15: 86: 17.65		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		254285 LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Hs
		1259459 LRP1B_HUMAN (4-204): 6.71e-09: 64.9: 16.16		NET5_HUMAN (1-489): 1.06e-87: 278: 100.00
+	Dm
		1098542 Q8IRV8_DROME (25-99): 2.91e-11: 72.8: 41.77		NETB_DROME (143-472): 9.84e-53: 192: 31.10
+	Dm
		52252 A1Z7C4_DROME (3664-3865): 6.19e-09: 65.2: 21.20		LAMC1_DROME (20-327): 1.21e-27: 119: 15.82
+	Hs
		502808 NID1_HUMAN (308-418): 7.69e-09: 64.5: 17.89		LAMC1_HUMAN (124-444): 6.82e-27: 117: 18.77
+	Hs
		537530 NID1_HUMAN (308-418): 7.69e-09: 64.5: 17.89		LAMC3_HUMAN (20-326): 3.25e-27: 117: 17.98
+	Dm
		52251 A1Z7C4_DROME (3664-3865): 6.19e-09: 65.2: 21.20		LAMB1_DROME (19-313): 5.72e-17: 86.4: 17.59
+	Mm
		358675 NID1_MOUSE (2773-2970): 3.23e-09: 65.6: 13.86		LAMC1_MOUSE (240-449): 3.8e-14: 77.5: 13.33
+	Dm
		52257 A1Z7C4_DROME (3664-3865): 6.19e-09: 65.2: 21.20		LAMA_DROME (4-222): 2.52e-11: 68.7: 11.71