Protein: RN111
E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)

Gene: RN111, RNF111
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q6ZNA4

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982217

UB2D2
Ubiquitin-conjugating enzyme E2 D2

8

20

Small-scale

0.969

High

1252746

RN111
E3 ubiquitin-protein ligase Arkadia

7

14

Small-scale

0.965

High

957108

UB2D3
Ubiquitin-conjugating enzyme E2 D3

6

20

Small-scale

0.955

High

957769

UBE2N
Ubiquitin-conjugating enzyme E2 N

5

20

Small-scale

0.917

High

906684

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

High-throughput

0.914

High

993626

UBC9
SUMO-conjugating enzyme UBC9

3

20

High-throughput

0.884

High

909332

UB2E1
Ubiquitin-conjugating enzyme E2 E1

3

20

High-throughput

0.867

High

1252762

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

High-throughput

0.867

High

1252763

UBE2W
Ubiquitin-conjugating enzyme E2 W

3

20

High-throughput

0.867

High

957618

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

High-throughput

0.849

High

1252791

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

High-throughput

0.815

High

1252767

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.800

High

997809

CSK21
Casein kinase II subunit alpha

6

6

High-throughput

0.741

High

625453

CSK22
Casein kinase II subunit alpha'

6

9

High-throughput

0.732

High

1014539

SMAD3
Mothers against decapentaplegic homolog 3

5

9

Small-scale

0.702

High

952440

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

High-throughput

0.698

High

957423

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.698

High

1103910

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

685889

KRA59
Keratin-associated protein 5-9

4

3

High-throughput

0.697

High

320704

UBXN7
UBX domain-containing protein 7

3

7

High-throughput

0.681

High

964339

SUMO2
Small ubiquitin-related modifier 2

3

5

Small-scale

0.680

High

177692

SMAD7
Mothers against decapentaplegic homolog 7

4

9

Small-scale

0.680

High

991350

SUMO1
Small ubiquitin-related modifier 1

3

5

Small-scale

0.670

High

242059

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.665

High

555499

SKIL
Ski-like protein

3

4

Small-scale

0.664

High

1252758

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

High-throughput

0.663

High

714211

PML
Protein PML

3

4

Small-scale

0.658

High

995099

CSK2B
Casein kinase II subunit beta

3

2

High-throughput

0.650

High

508165

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

Small-scale

0.647

High

995980

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

1154270

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.647

High

555404

SKI
Ski oncogene

3

4

Small-scale

0.640

High

1153819

SMAD2
Mothers against decapentaplegic homolog 2

3

9

Small-scale

0.640

High

1004741

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.618

High

181131

AXIN1
Axin-1

2

3

Small-scale

0.586

High

396374

ESR1
Estrogen receptor

1

17

Small-scale

0.561

High

926367

BLM
RecQ-like DNA helicase BLM

1

5

Small-scale

0.561

High

1252759

EDAD
Ectodysplasin-A receptor-associated adapter protein

1

0

High-throughput

0.549

High

136702

TRAF5
TNF receptor-associated factor 5

1

7

High-throughput

0.541

High

540896

ERG
Transcriptional regulator ERG

1

8

High-throughput

0.541

High

623398

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

High-throughput

0.541

High

1248422

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

2

High-throughput

0.541

High

1252755

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

1

High-throughput

0.541

High

1252771

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.541

High

1252773

PHF7
E3 ubiquitin-protein ligase PHF7

1

3

High-throughput

0.541

High

1252775

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

4

High-throughput

0.541

High

1252779

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

2

High-throughput

0.541

High

1252782

APC11
Anaphase-promoting complex subunit 11

1

3

High-throughput

0.541

High

839572

HUTH
Histidine ammonia-lyase

1

1

High-throughput

0.536

High

1252774

LOXE3
Hydroperoxide isomerase ALOXE3

1

2

High-throughput

0.536

High

1252785

SPAST
Spastin

1

7

High-throughput

0.536

High

75513

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

593139

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.518

High

73656

B2R8Y4
cDNA, FLJ94117, highly similar to Homo sapiens actinin, alpha 3

1

3

High-throughput

0.515

High

361283

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.515

High

422393

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.515

High

686626

ELAV4
ELAV-like protein 4

1

3

High-throughput

0.515

High

843690

HD
Huntingtin

1

1

High-throughput

0.515

High

890007

PSN1
Presenilin-1

1

1

High-throughput

0.515

High

927036

ATX3
Ataxin-3

1

2

High-throughput

0.515

High

927369

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

1252760

NDRG1
Protein NDRG1

1

1

High-throughput

0.515

High

1252765

OPTN
Optineurin

1

2

High-throughput

0.515

High

893496

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

High-throughput

0.513

High

943849

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

1186952

KR151
Keratin-associated protein 15-1

1

0

High-throughput

0.513

High

1252748

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.513

High

1252772

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.513

High

1252784

RBM27
RNA-binding protein 27

1

0

High-throughput

0.513

High

1252787

ADDG
Gamma-adducin

1

0

High-throughput

0.513

High

1252788

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.513

High

1252789

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1252780

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

7

High-throughput

0.508

High

939200

SUMO3
Small ubiquitin-related modifier 3

1

5

Small-scale

0.501

High

387433

APOE
Apolipoprotein E

1

0

High-throughput

0.493

High

791477

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

1252769

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.493

High

1252781

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.493

High

1010484

EREP3
Protein ENTREP3

1

1

High-throughput

0.489

High

1252749

NRSN1
Neurensin-1

1

3

High-throughput

0.489

High

1252750

TTC9C
Tetratricopeptide repeat protein 9C

1

4

High-throughput

0.489

High

1252786

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

333062

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

6

High-throughput

0.481

High

684009

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

10

High-throughput

0.481

High

685241

PAX6
Paired box protein Pax-6

1

10

High-throughput

0.481

High

1059677

KRA11
Keratin-associated protein 1-1

1

2

High-throughput

0.481

High

1061527

ACTN3
Alpha-actinin-3

1

3

High-throughput

0.481

High

1252747

NT2NA
Notch homolog 2 N-terminal-like protein A

1

3

High-throughput

0.481

High

1252761

CBP
CREB-binding protein

1

3

Small-scale

0.481

High

1252776

TSYL1
Testis-specific Y-encoded-like protein 1

1

1

High-throughput

0.481

High

1252777

SDCB2
Syntenin-2

1

2

High-throughput

0.481

High

219870

SMAD6
Mothers against decapentaplegic homolog 6

1

9

Small-scale

0.479

High

461618

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

468519

HS90B
Heat shock protein HSP 90-beta

1

7

High-throughput

0.479

High

652532

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

16

Small-scale

0.479

High

674217

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

1032826

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

1123012

FHL2
Four and a half LIM domains protein 2

1

2

Small-scale

0.479

High

1156672

NF2L2
Nuclear factor erythroid 2-related factor 2

1

4

Small-scale

0.479

High

1239360

ESRP1
Epithelial splicing regulatory protein 1

1

3

Small-scale

0.479

High

1252754

CSK23
Casein kinase II subunit alpha 3

1

6

High-throughput

0.479

High

1252756

RBCC1
RB1-inducible coiled-coil protein 1

1

6

Small-scale

0.479

High

1252757

SETD7
Histone-lysine N-methyltransferase SETD7

1

3

Small-scale

0.479

High

1252778

ESRP2
Epithelial splicing regulatory protein 2

1

4

Small-scale

0.479

High

1252783

CDK12
Cyclin-dependent kinase 12

1

4

High-throughput

0.479

High

1252790

AXIN2
Axin-2

1

3

Small-scale

0.479

High

559

NBPFJ
NBPF family member NBPF19

1

0

High-throughput

0.460

High

960460

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.460

High

1103242

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.460

High

1131965

MVP
Major vault protein

1

0

High-throughput

0.460

High

1252766

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.460

High

1252770

MDFI
MyoD family inhibitor

1

0

High-throughput

0.460

High

540038

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.458

High

1252764

ARK2N
Protein ARK2N

1

0

Small-scale

0.458

High

139555

PESC
Pescadillo homolog

1

1

High-throughput

0.445

High

1241000

L2GL2
LLGL scribble cell polarity complex component 2

1

5

High-throughput

0.445

High

1252752

IN80E
INO80 complex subunit E

1

1

High-throughput

0.445

High

1252753

CAMKV
CaM kinase-like vesicle-associated protein

1

3

High-throughput

0.445

High

1252792

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.445

High

1059879

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.438

High

1252768

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

336198

TNF6B
Tumor necrosis factor receptor superfamily member 6B

1

5

High-throughput

0.407

High

516105

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

1252751

SYT2
Synaptotagmin-2

1

1

High-throughput

0.407

High

1215105

LCE4A
Late cornified envelope protein 4A

1

0

High-throughput

0.299

High


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Last updated: 11Aug2025