HitPredict

Interactor 1: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Interactor 2: XAF1 (Q6GPH4)
XIAP-associated factor 1 (BIRC4-binding protein)
Gene: XAF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.717

Property	Details
Experiments	23323858, 33130818, 11175744, 17613533, 22811387
Identification Methods	affinity chromatography technology, two hybrid, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 497 Hs			1 301
+	Hs
		1036285 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		XAF1_HUMAN (1-301): 4.22e-179: 497: 100.00
+	Hs
		1035824 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		XAF1_HUMAN (1-301): 4.22e-179: 497: 100.00
+	Hs
		1151548 BIRC7_HUMAN (14-155): 1.47e-36: 138: 21.83		XAF1_HUMAN (1-301): 4.22e-179: 497: 100.00
+	Hs
		1023639 BIRC1_HUMAN (4-108): 9.9e-28: 119: 32.38		XAF1_HUMAN (1-301): 4.22e-179: 497: 100.00
+	Hs
		1151542 LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45		XAF1_HUMAN (1-301): 4.22e-179: 497: 100.00