HitPredict

Interactor 1: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Interactor 2: CASPC (Q6UXS9)
Inactive caspase-12 (CASP-12)
Gene: CASP12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23074197
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14, CARD~zf-C3HC4_3
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 497 Hs			1 341
+	Hs
		830276 XIAP_HUMAN (1-497): 0: 569: 100.00		CASP4_HUMAN (3-341): 2.19e-128: 374: 46.83
+	Hs
		876972 XIAP_HUMAN (1-497): 0: 569: 100.00		CASP9_HUMAN (10-337): 1.47e-109: 327: 19.77
+	Hs
		957707 XIAP_HUMAN (1-497): 0: 569: 100.00		CASP8_HUMAN (10-338): 5.84e-106: 320: 17.24
+	Hs
		876939 XIAP_HUMAN (1-497): 0: 569: 100.00		CASP7_HUMAN (46-337): 1.88e-102: 305: 18.91
+	Rn
		1337442 XIAP_RAT (1-497): 0: 549: 89.14		Q9JHK1_RAT (35-337): 2.82e-106: 320: 22.29
+	Hs
		788182 XIAP_HUMAN (1-497): 0: 569: 100.00		CASP3_HUMAN (52-338): 9.43e-99: 294: 23.68
+	Hs
		877014 XIAP_HUMAN (1-497): 0: 569: 100.00		CASP6_HUMAN (72-339): 3.62e-94: 283: 19.57
+	Mm
		957027 XIAP_MOUSE (1-497): 0: 544: 88.73		CASP7_MOUSE (47-337): 9.49e-104: 308: 20.90
+	Mm
		936913 XIAP_MOUSE (1-497): 0: 544: 88.73		CASP3_MOUSE (52-338): 1.26e-97: 291: 22.37
+	Hs
		957749 XIAP_HUMAN (1-497): 0: 569: 100.00		CASPA_HUMAN (63-296): 1.63e-75: 243: 20.94
+	Hs
		876981 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		CASP9_HUMAN (10-337): 1.47e-109: 327: 19.77
+	Hs
		788252 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		CASP2_HUMAN (40-341): 9.88e-107: 321: 22.68
+	Hs
		1036271 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		CASP8_HUMAN (10-338): 5.84e-106: 320: 17.24
+	Hs
		876945 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		CASP7_HUMAN (46-337): 1.88e-102: 305: 18.91
+	Hs
		788194 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		CASP3_HUMAN (52-338): 9.43e-99: 294: 23.68
+	Hs
		667461 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		CASP1_HUMAN (1-341): 3.38e-126: 369: 36.92
+	Hs
		1036308 BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31		CASPA_HUMAN (63-296): 1.63e-75: 243: 20.94
+	Hs
		876944 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		CASP7_HUMAN (46-337): 1.88e-102: 305: 18.91
+	Hs
		788193 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		CASP3_HUMAN (52-338): 9.43e-99: 294: 23.68
+	Hs
		181612 BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94		CFLAR_HUMAN (69-337): 1.67e-72: 234: 16.48