HitPredict

Interactor 1: RAP1B (P61224)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 676
+	Hs
		958051 RAB14_HUMAN (4-178): 7.99e-69: 209: 33.52		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Hs
		375023 RASH_HUMAN (1-167): 1.23e-55: 175: 57.49		GAB2_HUMAN (1-676): 0: 566: 100.00
+	Hs
		988340 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		976248 RB11A_HUMAN (4-178): 2.13e-69: 211: 28.98		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		374572 RASH_HUMAN (1-167): 1.23e-55: 175: 57.49		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Hs
		375489 RASK_HUMAN (1-167): 6.29e-55: 174: 57.49		GAB1_HUMAN (3-675): 6.62e-143: 434: 37.07
+	Mm
		988900 RAC1_MOUSE (1-184): 1.74e-77: 231: 27.55		RHG22_MOUSE (5-537): 2.35e-69: 241: 14.07
+	Hs
		988484 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		RHG22_HUMAN (5-539): 2e-49: 186: 12.71
+	Hs
		1430476 RAB1B_HUMAN (4-179): 1.12e-71: 216: 29.94		PKHA2_HUMAN (2-229): 1.11e-46: 173: 21.55
+	Hs
		988724 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		PKHA1_HUMAN (7-205): 1.02e-32: 132: 19.80
+	Hs
		319060 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		K0754_HUMAN (34-655): 3.25e-28: 123: 10.69
+	Hs
		375620 RASK_HUMAN (1-167): 6.29e-55: 174: 57.49		PKHA7_HUMAN (6-454): 6.89e-45: 174: 13.48
+	Hs
		976574 RB11A_HUMAN (4-178): 2.13e-69: 211: 28.98		PKHA1_HUMAN (7-205): 1.02e-32: 132: 19.80
+	Hs
		1324054 RIT2_HUMAN (2-178): 1.4e-54: 174: 46.89		RHG24_HUMAN (7-597): 1.82e-41: 163: 14.24
+	Hs
		988490 RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55		PHLB2_HUMAN (9-113): 1.51e-22: 105: 28.30
+	Hs
		319043 RASK_HUMAN (1-167): 6.29e-55: 174: 57.49		K0754_HUMAN (34-655): 3.25e-28: 123: 10.69
+	Hs
		374716 RASH_HUMAN (1-167): 1.23e-55: 175: 57.49		PHLB2_HUMAN (9-113): 1.51e-22: 105: 28.30
+	Hs
		375669 RASK_HUMAN (1-167): 6.29e-55: 174: 57.49		PHLB2_HUMAN (9-113): 1.51e-22: 105: 28.30
+	Hs
		374719 RASH_HUMAN (1-167): 1.23e-55: 175: 57.49		PHLB1_HUMAN (8-113): 2.48e-16: 85.5: 26.27
+	Hs
		215890 RASK_HUMAN (1-167): 6.29e-55: 174: 57.49		SYNJ1_HUMAN (219-635): 5.66e-13: 74.8: 11.91