HitPredict

Interactor 1: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Interactor 2: RHG22 (Q8BL80)
Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) (p68RacGAP)
Gene: Arhgap22

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	14966113
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 702
+	Hs
		260707 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		OPHN1_HUMAN (11-589): 2.01e-94: 311: 17.54
+	Hs
		65907 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG42_HUMAN (11-626): 9.91e-92: 306: 17.44
+	Hs
		988431 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG21_HUMAN (76-671): 3.32e-87: 302: 19.43
+	Hs
		988442 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG17_HUMAN (44-606): 2.45e-89: 300: 20.00
+	Hs
		988402 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG44_HUMAN (68-580): 2.73e-81: 276: 18.01
+	Hs
		212765 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		SRGP3_HUMAN (76-644): 4.36e-78: 272: 17.55
+	Hs
		67650 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG32_HUMAN (86-615): 2.14e-73: 261: 16.30
+	Hs
		156404 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG33_HUMAN (86-516): 3.99e-72: 257: 18.12
+	Hs
		269537 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		SRGP2_HUMAN (68-652): 1.69e-72: 256: 16.91
+	Mm
		988897 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		RHG32_MOUSE (86-601): 7.49e-71: 254: 16.76
+	Hs
		586979 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		CHIN_HUMAN (68-355): 1.93e-74: 249: 22.03
+	Hs
		988417 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG15_HUMAN (18-360): 1.91e-72: 244: 18.40
+	Mm
		988896 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		CHIO_MOUSE (24-355): 4.27e-73: 241: 20.99
+	Hs
		914009 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		CHIO_HUMAN (156-355): 2.21e-69: 236: 29.56
+	Hs
		988328 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG05_HUMAN (159-381): 1.03e-64: 235: 27.23
+	Hs
		988468 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG27_HUMAN (157-357): 9.27e-64: 229: 30.05
+	Hs
		988313 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RHG01_HUMAN (159-359): 1.53e-65: 225: 30.35
+	Mm
		988885 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		RHG01_MOUSE (159-362): 1.7e-65: 225: 29.90
+	Hs
		324254 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		FA13A_HUMAN (179-361): 2.53e-20: 98.2: 35.68
+	Mm
		988887 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		ABR_MOUSE (157-342): 8.44e-20: 96.3: 31.75