HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RSLAA (Q92737)
Ras-like protein family member 10A (EC 3.6.5.2) (Ras-like protein RRP22) (Ras-related protein on chromosome 22)
Gene: RASL10A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0003925 - G protein activity GO:0005525 - GTP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 203
+	Hs
		955905 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAB8A_HUMAN (5-196): 1.21e-77: 233: 22.40
+	Hs
		955911 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RAB8A_HUMAN (5-196): 1.21e-77: 233: 22.40
+	Hs
		961930 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAB1A_HUMAN (4-200): 3.98e-76: 229: 20.19
+	Hs
		959311 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAP1B_HUMAN (5-197): 2.94e-76: 228: 29.02
+	Hs
		981255 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RAB1A_HUMAN (4-200): 3.98e-76: 229: 20.19
+	Hs
		959316 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RAP1B_HUMAN (5-197): 2.94e-76: 228: 29.02
+	Hs
		962463 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAB1B_HUMAN (4-200): 2.14e-75: 226: 19.81
+	Hs
		988691 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RAB1B_HUMAN (4-200): 2.14e-75: 226: 19.81
+	Hs
		956235 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAB2A_HUMAN (4-197): 8.87e-74: 223: 20.10
+	Hs
		976191 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RB11A_HUMAN (4-198): 5.25e-74: 224: 20.51
+	Hs
		956241 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RAB2A_HUMAN (4-197): 8.87e-74: 223: 20.10
+	Hs
		901166 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAB7A_HUMAN (5-186): 6.79e-64: 198: 25.14
+	Hs
		988585 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RIT1_HUMAN (5-193): 1.08e-64: 200: 28.04
+	Hs
		539791 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RALA_HUMAN (6-182): 2.49e-63: 196: 28.81
+	Hs
		901174 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RAB7A_HUMAN (5-186): 6.79e-64: 198: 25.14
+	Hs
		959435 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAP2B_HUMAN (17-184): 2.54e-63: 196: 29.17
+	Hs
		962661 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RAP2C_HUMAN (17-185): 2.28e-62: 193: 28.40
+	Hs
		988850 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RAP2C_HUMAN (17-185): 2.28e-62: 193: 28.40
+	Hs
		466084 RHOC_HUMAN (1-193): 1.75e-77: 231: 91.71		RALA_HUMAN (6-182): 2.49e-63: 196: 28.81
+	Hs
		988386 RAC1_HUMAN (1-193): 7e-79: 235: 57.22		RHEB_HUMAN (4-175): 1.61e-13: 67.8: 26.86