Protein: RHEB
GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain)

Gene: RHEB
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q15382

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

839279

MTOR
Serine/threonine-protein kinase mTOR

9

16

Small-scale

0.974

High

890831

TSC2
Tuberin

7

11

Small-scale

0.971

High

400873

RAF1
RAF proto-oncogene serine/threonine-protein kinase

5

20

Small-scale

0.927

High

578487

BRAF
Serine/threonine-protein kinase B-raf

3

20

Small-scale

0.827

High

988386

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

High-throughput

0.811

High

1103752

PLD1
Phospholipase D1

1

3

Small-scale

0.747

High

1102169

ATM
Serine-protein kinase ATM

1

14

Small-scale

0.724

High

1147488

RPTOR
Regulatory-associated protein of mTOR

5

6

Small-scale

0.713

High

564826

NCAM1
Neural cell adhesion molecule 1

1

3

High-throughput

0.698

High

593376

PGFRA
Platelet-derived growth factor receptor alpha

1

8

High-throughput

0.691

High

1125446

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

3

1

Small-scale

0.669

High

650172

FGFR3
Fibroblast growth factor receptor 3

1

15

High-throughput

0.665

High

981503

RAN
GTP-binding nuclear protein Ran

1

20

High-throughput

0.665

High

231394

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

3

3

Small-scale

0.665

High

1109450

ATR
Serine/threonine-protein kinase ATR

1

14

Small-scale

0.648

High

658604

KS6B1
Ribosomal protein S6 kinase beta-1

1

2

Small-scale

0.647

High

1147501

LST8
Target of rapamycin complex subunit LST8

3

3

Small-scale

0.640

High

378100

TNFA
Tumor necrosis factor

3

0

High-throughput

0.638

High

507198

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

14

High-throughput

0.628

High

1127342

CASL
Enhancer of filamentation 1

2

7

High-throughput

0.628

High

1147508

I20RA
Interleukin-20 receptor subunit alpha

2

5

High-throughput

0.628

High

1147514

SRPRB
Signal recognition particle receptor subunit beta

2

19

High-throughput

0.628

High

562064

LAMP2
Lysosome-associated membrane glycoprotein 2

2

20

High-throughput

0.621

High

1147512

PKHM1
Pleckstrin homology domain-containing family M member 1

1

10

Small-scale

0.618

High

374613

RASH
GTPase HRas

1

20

Small-scale

0.618

High

982086

RAP1A
Ras-related protein Rap-1A

1

19

Small-scale

0.618

High

1147504

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.618

High

1147505

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1147493

TSC1
Hamartin

2

20

Small-scale

0.595

High

230325

CREB3
Cyclic AMP-responsive element-binding protein 3

2

2

High-throughput

0.590

High

1107740

SQSTM
Sequestosome-1

2

8

High-throughput

0.584

High

1094555

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

Small-scale

0.578

High

1147489

RN152
E3 ubiquitin-protein ligase RNF152

1

5

Small-scale

0.578

High

541025

PIM1
Serine/threonine-protein kinase pim-1

1

5

High-throughput

0.575

High

1147498

AURKB
Aurora kinase B

1

2

High-throughput

0.575

High

843579

HD
Huntingtin

1

8

Small-scale

0.561

High

926999

ATX3
Ataxin-3

1

2

Small-scale

0.561

High

1147494

APBP2
Amyloid protein-binding protein 2

2

3

High-throughput

0.553

High

1147483

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1092048

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

2

Small-scale

0.552

High

1147481

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.546

High

369674

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.541

High

890736

PSN2
Presenilin-2

1

2

High-throughput

0.541

High

1147497

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.541

High

1147502

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

567403

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.536

High

182539

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.536

High

854074

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.536

High

854531

S15A1
Solute carrier family 15 member 1

1

4

High-throughput

0.536

High

868697

LEG7
Galectin-7

1

7

High-throughput

0.536

High

948064

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

1

High-throughput

0.536

High

1147482

ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

1

1

High-throughput

0.536

High

1147490

RELL2
RELT-like protein 2

1

1

High-throughput

0.536

High

1147506

STMN3
Stathmin-3

1

1

High-throughput

0.536

High

1147513

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

1147500

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.518

High

1090654

TRAF2
TNF receptor-associated factor 2

1

7

Small-scale

0.515

High

130958

HIP1
Huntingtin-interacting protein 1

1

5

High-throughput

0.515

High

280629

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

High-throughput

0.515

High

937003

CASP6
Caspase-6

1

1

High-throughput

0.515

High

1133864

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

9

High-throughput

0.515

High

1147510

UBQL1
Ubiquilin-1

1

11

High-throughput

0.515

High

488317

PPBI
Intestinal-type alkaline phosphatase

1

0

High-throughput

0.513

High

1147479

TM52B
Transmembrane protein 52B

1

0

High-throughput

0.513

High

1147487

VASH2
Tubulinyl-Tyr carboxypeptidase 2

1

0

High-throughput

0.513

High

239370

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

2

Small-scale

0.508

High

1147509

PRAF1
Prenylated Rab acceptor protein 1

1

14

Small-scale

0.508

High

335132

ARI2
E3 ubiquitin-protein ligase ARIH2

1

9

High-throughput

0.494

High

1062237

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.493

High

441536

CCKN
Cholecystokinin

1

0

High-throughput

0.493

High

1041996

LMNB2
Lamin-B2

1

6

High-throughput

0.489

High

1147499

TCPQM
T-complex protein 1 subunit theta-like 2

1

9

High-throughput

0.489

High

889987

PSN1
Presenilin-1

1

2

High-throughput

0.481

High

208507

PJA2
E3 ubiquitin-protein ligase Praja-2

1

17

Small-scale

0.479

High

293728

CD123
Translation initiation factor eIF2 assembly protein

1

5

High-throughput

0.479

High

404071

GCR
Glucocorticoid receptor

1

17

High-throughput

0.479

High

487344

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

683644

ITB8
Integrin beta-8

1

9

High-throughput

0.479

High

766576

PHB1
Prohibitin 1

1

13

High-throughput

0.479

High

947198

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

3

High-throughput

0.479

High

1040815

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

1147478

FSCN1
Fascin

1

1

High-throughput

0.479

High

1147480

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

1147492

DUS19
Dual specificity protein phosphatase 19

1

7

High-throughput

0.479

High

1147503

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

10

High-throughput

0.479

High

1147511

VPS4A
Vacuolar protein sorting-associated protein 4A

1

7

High-throughput

0.479

High

387421

APOE
Apolipoprotein E

1

0

High-throughput

0.460

High

551059

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

1147486

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1147496

SC5A5
Sodium/iodide cotransporter

1

0

Small-scale

0.458

High

730603

1433S
14-3-3 protein sigma

1

8

High-throughput

0.445

High

1147495

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.445

High

105978

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

372093

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

588763

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.437

High

695529

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

12

High-throughput

0.437

High

768259

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

879120

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

1147484

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1147507

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

2

Small-scale

0.437

High

1147485

SPT19
Spermatogenesis-associated protein 19, mitochondrial

2

0

High-throughput

0.328

High

1147491

NF2IP
NFATC2-interacting protein

2

0

High-throughput

0.328

High

1147515

Q9Y649
GW128

1

0

High-throughput

0.268

Low

254613

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025