Protein: DEF1
Neutrophil defensin 1 (Defensin, alpha 1) (HNP-1) (HP-1) (HP1) [Cleaved into: HP 1-56; Neutrophil defensin 2 (HNP-2) (HP-2) (HP2)]

Gene: DEF1, DEFA1
Organism: Homo sapiens
Interactions: 113
UniProt ID: P59665

Gene Ontology (top 5):
GO:0002227 - innate immune response in mucosa
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005796 - Golgi lumen
GO:0006935 - chemotaxis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

165176

PLXB2
Plexin-B2

2

5

High-throughput

0.628

High

172654

LAMA5
Laminin subunit alpha-5

2

4

High-throughput

0.628

High

203026

COCH
Cochlin

2

3

High-throughput

0.628

High

296649

SLIT2
Slit homolog 2 protein

2

1

High-throughput

0.628

High

419181

ITAV
Integrin alpha-V

2

2

High-throughput

0.628

High

433135

LAMB1
Laminin subunit beta-1

2

4

High-throughput

0.628

High

517940

CO6A1

2

1

High-throughput

0.628

High

528088

BMP1
Bone morphogenetic protein 1

2

3

High-throughput

0.628

High

550460

ARSB
Arylsulfatase B

2

4

High-throughput

0.628

High

574113

IBP2
Insulin-like growth factor-binding protein 2

2

3

High-throughput

0.628

High

612836

FBLN1
Fibulin-1

2

2

High-throughput

0.628

High

869936

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

2

2

High-throughput

0.628

High

877399

LAMB2
Laminin subunit beta-2

2

4

High-throughput

0.628

High

887025

TGBR3
Transforming growth factor beta receptor type 3

2

1

High-throughput

0.628

High

887033

NID2
Nidogen-2

2

2

High-throughput

0.628

High

887035

LAMA3
Laminin subunit alpha-3

2

5

High-throughput

0.628

High

887036

T132A
Transmembrane protein 132A

2

1

High-throughput

0.628

High

887047

CILP2
Cartilage intermediate layer protein 2

2

1

High-throughput

0.628

High

887049

SULF2
Extracellular sulfatase Sulf-2

2

4

High-throughput

0.628

High

887053

PXDN
Peroxidasin homolog

2

1

High-throughput

0.628

High

887060

PADC1
Protease-associated domain-containing protein 1

2

1

High-throughput

0.628

High

887065

CNTP3
Contactin-associated protein-like 3

2

1

High-throughput

0.628

High

887067

SMOC1
SPARC-related modular calcium-binding protein 1

2

2

High-throughput

0.628

High

887070

CATF
Cathepsin F

2

2

High-throughput

0.628

High

887073

PLXA1
Plexin-A1

2

5

High-throughput

0.628

High

887078

LOXL2
Lysyl oxidase homolog 2

2

1

High-throughput

0.628

High

887019

DEF1
Neutrophil defensin 1

1

3

High-throughput

0.618

High

887064

ACE2
Angiotensin-converting enzyme 2

2

1

Small-scale

0.602

High

280223

CBPD
Carboxypeptidase D

2

0

High-throughput

0.602

High

305300

NXPH4
Neurexophilin-4

2

0

High-throughput

0.602

High

341547

TPA
Tissue-type plasminogen activator

2

0

High-throughput

0.602

High

351324

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

2

0

High-throughput

0.602

High

413031

CHLE
Cholinesterase

2

0

High-throughput

0.602

High

531097

EF2
Elongation factor 2

2

0

High-throughput

0.602

High

660448

GRN
Progranulin

2

0

High-throughput

0.602

High

760520

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

0

High-throughput

0.602

High

782073

WNT5A
Protein Wnt-5a

2

0

High-throughput

0.602

High

789669

LIFR
Leukemia inhibitory factor receptor

2

0

High-throughput

0.602

High

887020

NPC2
NPC intracellular cholesterol transporter 2

2

0

High-throughput

0.602

High

887024

DIAC
Di-N-acetylchitobiase

2

0

High-throughput

0.602

High

887026

COEA1
Collagen alpha-1(XIV) chain

2

0

High-throughput

0.602

High

887038

TKFC
Triokinase/FMN cyclase

2

0

High-throughput

0.602

High

887051

SCRB1
Scavenger receptor class B member 1

2

0

High-throughput

0.602

High

887058

LGMN
Legumain

2

0

High-throughput

0.602

High

887069

ERAP1
Endoplasmic reticulum aminopeptidase 1

2

0

High-throughput

0.602

High

887072

CEIP2
Inactive cell surface hyaluronidase CEMIP2

2

0

High-throughput

0.602

High

887075

NOTC3
Neurogenic locus notch homolog protein 3

2

0

High-throughput

0.602

High

225295

H6ST1
Heparan-sulfate 6-O-sulfotransferase 1

2

1

High-throughput

0.574

High

253459

PLXA2
Plexin-A2

2

5

High-throughput

0.574

High

557532

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

2

2

High-throughput

0.574

High

819142

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

2

2

High-throughput

0.574

High

887028

PP2BA
Protein phosphatase 3 catalytic subunit alpha

2

2

High-throughput

0.574

High

887032

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

2

2

High-throughput

0.574

High

887044

SUSD1
Sushi domain-containing protein 1

2

6

High-throughput

0.574

High

887062

MCMBP
Mini-chromosome maintenance complex-binding protein

2

1

High-throughput

0.574

High

887066

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

2

2

High-throughput

0.574

High

887068

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

2

2

High-throughput

0.574

High

887079

LRP12
Low-density lipoprotein receptor-related protein 12

2

2

High-throughput

0.574

High

887071

UBQL2
Ubiquilin-2

2

2

High-throughput

0.553

High

234426

NRP2
Neuropilin-2

1

2

High-throughput

0.536

High

338208

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.536

High

709243

GALNS
N-acetylgalactosamine-6-sulfatase

1

4

High-throughput

0.536

High

726507

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

887037

MICA
MHC class I polypeptide-related sequence A

1

1

High-throughput

0.536

High

887045

ARSK
Arylsulfatase K

1

4

High-throughput

0.536

High

887056

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

2

High-throughput

0.536

High

198427

KLK10
Kallikrein-10

1

0

High-throughput

0.513

High

245803

CATL2
Cathepsin L2

1

0

High-throughput

0.513

High

607755

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.513

High

686628

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

887022

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

0

High-throughput

0.513

High

887029

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

1

0

High-throughput

0.513

High

887030

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.513

High

887043

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.513

High

887055

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.513

High

448878

MMP7
Matrilysin

1

1

Small-scale

0.501

High

838515

MMP14
Matrix metalloproteinase-14

1

1

Small-scale

0.501

High

351060

LDLR
Low-density lipoprotein receptor

1

2

High-throughput

0.489

High

443057

ITA5
Integrin alpha-5

1

2

High-throughput

0.489

High

887041

CAHD1
VWFA and cache domain-containing protein 1

1

2

High-throughput

0.489

High

887050

TTC13
Tetratricopeptide repeat protein 13

1

1

High-throughput

0.489

High

887063

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

3

High-throughput

0.489

High

835621

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.464

High

887048

TEX14
Inactive serine/threonine-protein kinase TEX14

1

1

High-throughput

0.445

High

197893

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

0

High-throughput

0.426

High

129472

MANBA
Beta-mannosidase

2

0

High-throughput

0.328

High

253634

IGSF3
Immunoglobulin superfamily member 3

2

0

High-throughput

0.328

High

674598

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

2

0

High-throughput

0.328

High

887021

CANB1
Calcineurin subunit B type 1

2

0

High-throughput

0.328

High

887027

ZO1
Tight junction protein ZO-1

2

0

High-throughput

0.328

High

887039

MKS3
Meckelin

2

0

High-throughput

0.328

High

887040

AB17B
Alpha/beta hydrolase domain-containing protein 17B

2

0

High-throughput

0.328

High

887046

UBE3D
E3 ubiquitin-protein ligase E3D

2

0

High-throughput

0.328

High

887052

TM131
Transmembrane protein 131

2

0

High-throughput

0.328

High

887061

CNPY3
Protein canopy homolog 3

2

0

High-throughput

0.328

High

206902

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.279

Low

830068

MA2A2
Alpha-mannosidase 2x

1

0

High-throughput

0.279

Low

887023

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.279

Low

887031

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

887034

NPTX1
Neuronal pentraxin-1

1

0

High-throughput

0.279

Low

887042

PLB1
Phospholipase B1, membrane-associated

1

0

High-throughput

0.279

Low

887054

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.279

Low

887074

FBX4
F-box only protein 4

1

0

High-throughput

0.279

Low

260485

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

346360

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

887059

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.249

Low

887076

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

887077

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

0

Small-scale

0.249

Low

245956

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.238

Low

563291

ZNF16
Zinc finger protein 16

1

0

Small-scale

0.238

Low

254461

ROCK2
Rho-associated protein kinase 2

1

0

High-throughput

0.232

Low

887057

SRPK1
SRSF protein kinase 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024