HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: RASF6 (Q6ZTQ3)
Ras association domain-containing protein 6
Gene: RASSF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	29931788, 24003224
Identification Methods	biochemical, affinity chromatography technology, pull down
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 491 Hs			1 369
+	Rn
		88795 D3ZVH5_RAT (1-490): 0: 635: 78.16		RASF6_RAT (33-369): 5.28e-160: 453: 74.85
+	Hs
		962989 MDM2_HUMAN (1-491): 0: 710: 100.00		RASF1_HUMAN (191-359): 9.68e-63: 205: 28.90
+	Hs
		962886 MDM2_HUMAN (1-491): 0: 710: 100.00		RASF5_HUMAN (191-359): 4.12e-46: 164: 26.01
+	Hs
		962849 MDM2_HUMAN (1-491): 0: 710: 100.00		RASF3_HUMAN (230-359): 2.89e-42: 149: 23.31
+	Mm
		620858 MDM2_MOUSE (1-490): 0: 639: 80.24		RASF1_MOUSE (191-359): 7.45e-62: 203: 28.90
+	Mm
		620841 MDM2_MOUSE (1-490): 0: 639: 80.24		RASF5_MOUSE (191-359): 3.08e-49: 172: 26.01