HitPredict

Interactor 1: FOXK2 (Q01167)
Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)
Gene: FOXK2

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.690

Property	Details
Experiments	25609649, 24748658, 27773593
Identification Methods	affinity chromatography technology, pull down, biochemical, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 660 Hs			1 1273
+	Hs
		952858 FOXK1_HUMAN (34-627): 5.33e-81: 273: 53.57		SIN3A_HUMAN (1-1273): 0: 1545: 100.00
+	Mm
		785686 FOXK1_MOUSE (34-627): 4.1e-76: 259: 53.40		SIN3B_MOUSE (110-1273): 0: 1237: 51.12
+	Ce
		60829 FOXO_CAEEL (212-554): 4.2e-55: 198: 19.02		SIN3_CAEEL (60-1079): 0: 716: 19.90
+	Hs
		257765 FOXK2_HUMAN (35-660): 2.35e-129: 397: 100.00		SIN3B_HUMAN (20-331): 1.12e-13: 78.4: 16.15
+	Sc
		609097 FKH1_YEAST (33-424): 9.51e-79: 260: 21.50		SIN3_YEAST (20-499): 1.06e-32: 140: 14.02
+	Sc
		609102 FKH2_YEAST (33-602): 3.79e-69: 243: 20.00		SIN3_YEAST (20-499): 1.06e-32: 140: 14.02