HitPredict

Interactor 1: EWS (Q01844)
RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
Gene: EWSR1

Interactor 2: TRAF3 (Q13114)
TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
Gene: TRAF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	35271311, 21988832
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 656 Hs			1 568
+	Mm
		1141404 EWS_MOUSE (1-656): 4.67e-42: 163: 94.06		TRAF3_MOUSE (1-568): 3.65e-163: 478: 96.13
+	Hs
		967138 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TRAF2_HUMAN (11-565): 1.77e-110: 340: 30.21
+	Hs
		967142 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TRAF1_HUMAN (151-563): 2.25e-80: 260: 32.63
+	Hs
		727114 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		TRAF6_HUMAN (22-562): 7.2e-84: 272: 21.28
+	Hs
		118604 EYA2_HUMAN (27-278): 1.48e-18: 91.3: 20.16		TRAF4_HUMAN (37-562): 2.06e-77: 254: 23.15
+	Hs
		726813 FUS_HUMAN (55-545): 1.15e-31: 131: 30.35		TRI25_HUMAN (46-374): 4.38e-42: 162: 16.08
+	Hs
		967532 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		RN114_HUMAN (46-200): 7.9e-28: 113: 15.92
+	Hs
		301769 EWS_HUMAN (1-656): 1.54e-47: 179: 100.00		TRI37_HUMAN (39-322): 1.6e-14: 78.9: 12.98