HitPredict

Interactor 1: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Interactor 2: PINK1 (Q9BXM7)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Gene: PINK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 901 Hs			1 581
+	Hs
		1055851 DSC3_HUMAN (1-901): 0: 806: 66.70		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Hs
		701695 DSG3_HUMAN (111-899): 0: 620: 29.13		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Hs
		521749 CADH1_HUMAN (28-897): 0: 714: 28.09		AKT1_HUMAN (115-573): 2.58e-118: 360: 12.89
+	Hs
		521711 CADH1_HUMAN (28-897): 0: 714: 28.09		KAPCA_HUMAN (173-567): 1.06e-110: 336: 13.89
+	Hs
		522043 CADH1_HUMAN (28-897): 0: 714: 28.09		KCC1D_HUMAN (204-577): 2.56e-101: 313: 16.75
+	Hs
		970837 DSG1_HUMAN (130-573): 2.65e-65: 239: 33.18		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Hs
		996007 DSC1_HUMAN (4-464): 2.89e-45: 178: 14.46		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Hs
		681797 DSG1_HUMAN (130-573): 2.65e-65: 239: 33.18		AKT1_HUMAN (115-573): 2.58e-118: 360: 12.89
+	Hs
		1048653 DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18		PINK1_HUMAN (1-581): 7.17e-159: 468: 100.00
+	Xl
		292722 O93264_XENLA (4-345): 2.86e-43: 171: 19.07		AKT1_XENLA (115-573): 7.09e-121: 367: 13.90
+	Hs
		970859 DSG1_HUMAN (130-573): 2.65e-65: 239: 33.18		KCC2A_HUMAN (221-538): 5.11e-82: 266: 20.62
+	Hs
		1048588 DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18		KS6A2_HUMAN (197-576): 4.99e-92: 300: 15.42