HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: FRMD6 (Q96NE9)
FERM domain-containing protein 6 (Willin)
Gene: FRMD6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.703

Property	Details
Experiments	31980649, 35271311, 36931259, 28514442, unassigned2173
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008104 - intracellular protein localization GO:0035332 - positive regulation of hippo signaling
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 255 Hs			1 622
+	Hs
		971460 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		PTN13_HUMAN (14-401): 8.53e-120: 394: 24.49
+	Hs
		708841 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		PTN4_HUMAN (4-536): 8.73e-120: 379: 14.29
+	Hs
		971997 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		E41L1_HUMAN (18-573): 2.36e-114: 364: 15.00
+	Hs
		972158 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		E41L3_HUMAN (13-569): 1.1e-111: 361: 13.81
+	Hs
		538935 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		EPB41_HUMAN (14-572): 1.19e-110: 353: 14.83
+	Hs
		217418 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		E41L2_HUMAN (13-545): 1.19e-105: 343: 12.70
+	Hs
		683983 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		PTN3_HUMAN (5-547): 9.84e-102: 331: 14.19
+	Mm
		972263 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		FRM4A_MOUSE (12-334): 6.23e-85: 288: 19.64
+	Mm
		972299 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		FRM4B_MOUSE (12-379): 1.15e-74: 260: 19.06
+	Hs
		971558 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		PTN14_HUMAN (20-336): 1.44e-73: 258: 19.75