HitPredict

Interactor 1: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Interactor 2: SIK2 (Q9H0K1)
Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
Gene: SIK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	36931259, 25852190, 24129571
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 255 Hs			1 926
+	Hs
		943639 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		SIK1_HUMAN (4-653): 8.35e-161: 492: 49.62
+	Hs
		972043 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		SNRK_HUMAN (17-437): 6.98e-155: 476: 35.21
+	Hs
		972160 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		SIK3_HUMAN (3-908): 2.37e-147: 471: 32.39
+	Mm
		972294 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		MARK1_MOUSE (15-677): 3.56e-151: 467: 31.32
+	Hs
		692031 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		MARK3_HUMAN (8-677): 3.85e-150: 463: 30.47
+	Hs
		972078 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		MARK1_HUMAN (15-677): 1.02e-149: 463: 30.94
+	Mm
		972206 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		MARK3_MOUSE (8-677): 1.32e-149: 462: 30.62
+	Hs
		971469 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		AAPK1_HUMAN (3-526): 3.85e-149: 454: 30.74
+	Hs
		971697 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		MARK2_HUMAN (1-673): 2.66e-146: 454: 31.29
+	Mm
		972209 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		MARK2_MOUSE (1-673): 2.81e-146: 454: 31.40
+	Xl
		237423 O57468_XENLA (1-255): 1.71e-152: 426: 96.47		Q804T2_XENLA (8-670): 4.01e-148: 457: 29.61
+	Rn
		930528 1433E_RAT (1-255): 4.89e-154: 430: 100.00		AAPK1_RAT (3-526): 1.28e-148: 453: 30.74
+	Hs
		930668 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		AAPK2_HUMAN (6-526): 6.63e-149: 453: 32.24
+	Xl
		237424 O57468_XENLA (1-255): 1.71e-152: 426: 96.47		Q8QGV3_XENLA (8-676): 4.58e-146: 453: 32.32
+	At
		1030913 14332_ARATH (4-255): 1.05e-147: 414: 74.41		CIPKC_ARATH (2-459): 2.25e-152: 460: 26.21
+	At
		840534 14333_ARATH (1-253): 3.47e-147: 413: 74.12		CIPKC_ARATH (2-459): 2.25e-152: 460: 26.21
+	At
		1379653 14337_ARATH (2-255): 7.77e-147: 412: 71.21		CIPKC_ARATH (2-459): 2.25e-152: 460: 26.21
+	Mm
		972284 1433E_MOUSE (1-255): 4.89e-154: 430: 100.00		MARK4_MOUSE (15-497): 1.49e-140: 438: 40.63
+	Hs
		971885 1433E_HUMAN (1-255): 4.89e-154: 430: 100.00		MARK4_HUMAN (15-497): 4.79e-140: 437: 41.02
+	Dm
		94942 1433E_DROME (1-254): 2.96e-146: 411: 82.69		E1JGN0_DROME (17-333): 6.43e-99: 337: 54.38