HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: 3BP2 (P78314)
SH3 domain-binding protein 2 (3BP-2)
Gene: SH3BP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9846481
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~SH2, PH~SH3_1, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0007165 - signal transduction GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 561
+	Hs
		440023 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		3BP2_HUMAN (1-561): 2.99e-100: 316: 100.00
+	Mm
		362445 ABL1_MOUSE (4-139): 4.08e-22: 95.9: 35.46		3BP2_MOUSE (1-561): 1.45e-106: 332: 86.63
+	Hs
		362239 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		3BP2_HUMAN (1-561): 2.99e-100: 316: 100.00
+	Hs
		584515 VAV_HUMAN (2-60): 7.9e-14: 71.6: 42.37		3BP2_HUMAN (1-561): 2.99e-100: 316: 100.00
+	Hs
		440483 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		3BP2_HUMAN (1-561): 2.99e-100: 316: 100.00
+	Hs
		1004318 VAV3_HUMAN (3-57): 2.47e-12: 67.1: 38.18		3BP2_HUMAN (1-561): 2.99e-100: 316: 100.00
+	Hs
		913638 VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18		3BP2_HUMAN (1-561): 2.99e-100: 316: 100.00
+	Hs
		215914 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SYNJ1_HUMAN (77-549): 3.83e-14: 77.9: 11.48
+	Hs
		590268 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MUC1_HUMAN (147-560): 2.14e-13: 75.6: 10.05
+	Hs
		987833 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PRG4_HUMAN (69-521): 1.67e-10: 66.4: 9.75
+	Hs
		551610 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		NFH_HUMAN (95-479): 5.28e-09: 61.2: 13.04
+	Hs
		215893 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SYNJ1_HUMAN (77-549): 3.83e-14: 77.9: 11.48
+	Hs
		439935 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MUC1_HUMAN (147-560): 2.14e-13: 75.6: 10.05
+	Hs
		440230 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		FMN2_HUMAN (202-477): 8.29e-10: 64.1: 20.50
+	Hs
		215903 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ1_HUMAN (77-549): 3.83e-14: 77.9: 11.48
+	Hs
		362149 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		MUC1_HUMAN (147-560): 2.14e-13: 75.6: 10.05
+	Hs
		215927 SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14		SYNJ1_HUMAN (77-549): 3.83e-14: 77.9: 11.48
+	Hs
		215925 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		SYNJ1_HUMAN (77-549): 3.83e-14: 77.9: 11.48
+	Hs
		440773 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MAGL2_HUMAN (228-561): 3.77e-11: 68.3: 10.98
+	Hs
		913671 VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18		TITIN_HUMAN (166-550): 4.36e-09: 61.7: 11.25