HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: LUZP1 (Q86V48)
Leucine zipper protein 1 (Filamin mechanobinding actin cross-linking protein) (Fimbacin)
Gene: LUZP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1076
+	Hs
		987809 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MY18A_HUMAN (72-652): 1.93e-31: 136: 12.91
+	Hs
		773152 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH10_HUMAN (1-608): 3.08e-28: 125: 11.11
+	Hs
		776799 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH11_HUMAN (3-537): 2.17e-23: 109: 13.19
+	Hs
		772723 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MYH9_HUMAN (1-353): 3.2e-12: 73.3: 13.65
+	Hs
		987653 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PLEC_HUMAN (35-503): 1.33e-11: 71.4: 16.50
+	Hs
		440112 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MRCKA_HUMAN (226-673): 1.22e-21: 104: 10.11
+	Hs
		440262 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MRCKB_HUMAN (255-633): 9e-21: 101: 11.11
+	Hs
		439934 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		DESP_HUMAN (44-616): 3.94e-15: 82.9: 10.48
+	Hs
		440658 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MY18A_HUMAN (72-652): 1.93e-31: 136: 12.91
+	Hs
		840958 ABL2_HUMAN (4-139): 9.65e-22: 94.7: 34.04		EEA1_HUMAN (1-532): 6.87e-22: 104: 10.40
+	Hs
		440097 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		GRDN_HUMAN (10-513): 1.42e-09: 64.9: 17.82
+	Hs
		1106309 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		ROCK1_HUMAN (83-619): 3.75e-26: 118: 12.09
+	Hs
		587548 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		DESP_HUMAN (44-616): 3.94e-15: 82.9: 10.48
+	Hs
		1141981 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		EEA1_HUMAN (1-532): 6.87e-22: 104: 10.40
+	Hs
		1154182 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		ITSN1_HUMAN (106-476): 2.88e-18: 93.3: 9.61
+	Hs
		440576 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		ITSN1_HUMAN (106-476): 2.88e-18: 93.3: 9.61
+	Hs
		440337 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		DESP_HUMAN (44-616): 3.94e-15: 82.9: 10.48
+	Hs
		1143227 Q96D37_HUMAN (2-60): 6.5e-14: 71.9: 42.37		PLEC_HUMAN (35-503): 1.33e-11: 71.4: 16.50
+	Hs
		584543 VAV_HUMAN (2-60): 7.9e-14: 71.6: 42.37		PLEC_HUMAN (35-503): 1.33e-11: 71.4: 16.50
+	Hs
		440414 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MYH9_HUMAN (1-353): 3.2e-12: 73.3: 13.65