HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 1210
+	Hs
		594080 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		EHMT2_HUMAN (21-1210): 0: 903: 100.00
+	Hs
		987940 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SUV92_HUMAN (928-1177): 2.73e-85: 285: 35.93
+	Hs
		440051 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		ANK3_HUMAN (525-1050): 7.05e-71: 263: 17.01
+	Hs
		594102 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SUV92_HUMAN (928-1177): 2.73e-85: 285: 35.93
+	Hs
		362377 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		SUV92_HUMAN (928-1177): 2.73e-85: 285: 35.93
+	Hs
		216365 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		SUV91_HUMAN (863-1177): 6.62e-88: 292: 31.71
+	Hs
		463836 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		ANR50_HUMAN (448-1080): 1.31e-83: 301: 17.45
+	Hs
		440727 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		SUV92_HUMAN (928-1177): 2.73e-85: 285: 35.93
+	Hs
		1154121 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		MIB1_HUMAN (541-1044): 1.19e-79: 285: 18.36
+	Hs
		463487 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		ANK3_HUMAN (525-1050): 7.05e-71: 263: 17.01
+	Hs
		987550 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		ANK2_HUMAN (6-555): 7.72e-11: 69: 10.97
+	Hs
		440239 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		KDIS_HUMAN (793-940): 9.41e-24: 111: 20.27
+	Hs
		362221 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		DAPK1_HUMAN (744-988): 3.96e-30: 131: 19.92
+	Hs
		440177 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		ASPP1_HUMAN (755-937): 2.38e-15: 83.5: 16.67
+	Hs
		274251 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		ANR17_HUMAN (708-1007): 4.56e-23: 109: 16.78
+	Hs
		463835 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		KDIS_HUMAN (793-940): 9.41e-24: 111: 20.27
+	Hs
		593966 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		ANK2_HUMAN (6-555): 7.72e-11: 69: 10.97
+	Hs
		463708 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		ASPP1_HUMAN (755-937): 2.38e-15: 83.5: 16.67
+	Hs
		463458 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		ANK2_HUMAN (6-555): 7.72e-11: 69: 10.97