HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: Q9NPR5 (Q9NPR5)
PTPRJ, protein tyrosine phosphatase receptor J, eta
Gene: Q9NPR5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	21706016
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 425
+	Hs
		987595 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PTPRJ_HUMAN (42-401): 8.24e-29: 121: 18.69
+	Hs
		389258 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		FINC_HUMAN (183-425): 4.18e-23: 104: 13.54
+	Hs
		439918 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRF_HUMAN (6-367): 2.42e-39: 152: 13.71
+	Hs
		440049 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRJ_HUMAN (42-401): 8.24e-29: 121: 18.69
+	Hs
		834183 CSK_HUMAN (2-139): 3.94e-24: 100: 36.24		PTPRJ_HUMAN (42-401): 8.24e-29: 121: 18.69
+	Hs
		440313 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		PTPRF_HUMAN (6-367): 2.42e-39: 152: 13.71
+	Hs
		440371 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		PTPRD_HUMAN (1-399): 5.08e-38: 149: 13.46
+	Mm
		59107 FYN_MOUSE (161-215): 9.17e-13: 68.5: 31.58		PTPRF_MOUSE (5-300): 1.82e-30: 126: 12.39
+	Hs
		439950 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		PTPRB_HUMAN (47-347): 2.27e-09: 61.9: 13.58
+	Hs
		593937 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		DCC_HUMAN (23-425): 1.92e-16: 84: 10.66
+	Hs
		388896 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		FINC_HUMAN (183-425): 4.18e-23: 104: 13.54
+	Dm
		362461 ABL_DROME (4-135): 1.01e-22: 97.4: 37.68		LAR_DROME (73-348): 7.21e-13: 72.8: 12.58
+	Hs
		388916 YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33		FINC_HUMAN (183-425): 4.18e-23: 104: 13.54
+	Hs
		440539 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		PTPRS_HUMAN (9-424): 1.09e-19: 94: 11.51
+	Hs
		658811 CSK_HUMAN (2-139): 3.94e-24: 100: 36.24		PTPRB_HUMAN (47-347): 2.27e-09: 61.9: 13.58
+	Hs
		913671 VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18		TITIN_HUMAN (33-263): 3.01e-10: 64.9: 14.73
+	Hs
		463561 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		SDK2_HUMAN (45-424): 8.56e-09: 60.1: 8.72