HitPredict

Interactor 1: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	27705803, 12004135, 24981860, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 406 Hs			1 183
+	Mm
		1321739 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		Q9DCC5_MOUSE (1-183): 1.62e-71: 215: 100.00
+	Mm
		613033 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		CBX3_MOUSE (1-183): 4.67e-71: 214: 99.45
+	Hs
		949760 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		CBX1_HUMAN (36-180): 1.02e-53: 170: 71.33
+	Mm
		193417 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		CBX8_MOUSE (21-116): 1.13e-26: 105: 32.00
+	Mm
		193405 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		CBX2_MOUSE (20-117): 6.27e-26: 104: 27.00
+	Mm
		193412 RING1_MOUSE (1-406): 2.17e-118: 352: 96.55		CBX7_MOUSE (21-101): 5.72e-26: 99.1: 35.29
+	Hs
		327842 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78
+	Hs
		123243 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		316019 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		988024 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		CBX8_HUMAN (21-116): 2.34e-26: 104: 32.00
+	Hs
		987972 RING1_HUMAN (1-406): 2.01e-114: 342: 100.00		CBX2_HUMAN (20-117): 5.97e-25: 102: 27.00
+	Mm
		1164651 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		Q6TKP2_MOUSE (21-124): 1.37e-30: 118: 27.78
+	Mm
		1321737 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		CBX6_MOUSE (21-124): 3.07e-29: 112: 27.78
+	Mm
		223231 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		CBX4_MOUSE (21-121): 3.91e-27: 108: 29.52
+	Hs
		327858 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		CBX7_HUMAN (21-181): 5.6e-29: 109: 22.78
+	Hs
		123308 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		CBX4_HUMAN (21-121): 4.95e-27: 108: 29.52
+	Hs
		316133 RING2_HUMAN (8-406): 4.9e-100: 302: 54.25		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Mm
		1321744 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		CBX8_MOUSE (21-116): 1.13e-26: 105: 32.00
+	Mm
		675501 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		CBX2_MOUSE (20-117): 6.27e-26: 104: 27.00
+	Mm
		1257537 RING2_MOUSE (8-406): 2.94e-100: 303: 54.25		CBX7_MOUSE (21-101): 5.72e-26: 99.1: 35.29