HitPredict

Interactor 1: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030276 - clathrin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 937 Hs			1 576
+	Rn
		312074 AP2B1_RAT (1-937): 0: 918: 100.00		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Hs
		988964 AP2B1_HUMAN (1-937): 0: 918: 100.00		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Hs
		1083233 AP1B1_HUMAN (1-937): 0: 880: 82.72		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Hs
		1083341 AP1B1_HUMAN (1-937): 0: 880: 82.72		EPN1_HUMAN (1-576): 7.54e-90: 290: 100.00
+	Rn
		986891 AP2B1_RAT (1-937): 0: 918: 100.00		EPN2_RAT (1-562): 2.37e-67: 231: 42.44
+	Hs
		329443 AP2B1_HUMAN (1-937): 0: 918: 100.00		EPN2_HUMAN (1-566): 1.15e-53: 194: 38.02
+	Dm
		1173112 Q24253_DROME (1-937): 0: 797: 71.75		Q8IN05_DROME (3-440): 9.99e-82: 281: 26.81
+	Hs
		215915 AP2B1_HUMAN (1-937): 0: 918: 100.00		SYNJ1_HUMAN (246-573): 8.4e-20: 96.3: 14.11
+	Dm
		1173116 Q24253_DROME (1-937): 0: 797: 71.75		Q9VD13_DROME (3-568): 1.06e-61: 217: 23.13
+	Hs
		215919 AP1B1_HUMAN (1-937): 0: 880: 82.72		SYNJ1_HUMAN (246-573): 8.4e-20: 96.3: 14.11
+	Hs
		344689 AP2A1_HUMAN (11-932): 0: 625: 16.97		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Hs
		344839 AP2A1_HUMAN (11-932): 0: 625: 16.97		EPN1_HUMAN (1-576): 7.54e-90: 290: 100.00
+	Rn
		93079 D3ZUY8_RAT (11-932): 0: 616: 17.14		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Rn
		312072 AP2A2_RAT (11-932): 0: 591: 16.50		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Hs
		323715 AP2A2_HUMAN (11-933): 0: 593: 16.99		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Hs
		323809 AP2A2_HUMAN (11-933): 0: 593: 16.99		EPN1_HUMAN (1-576): 7.54e-90: 290: 100.00
+	Rn
		312080 Q66HM2_RAT (11-932): 0: 586: 16.38		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Hs
		215889 AP2A1_HUMAN (11-932): 0: 625: 16.97		SYNJ1_HUMAN (246-573): 8.4e-20: 96.3: 14.11
+	Hs
		215887 AP2A2_HUMAN (11-933): 0: 593: 16.99		SYNJ1_HUMAN (246-573): 8.4e-20: 96.3: 14.11
+	Rn
		1224312 Q66HM2_RAT (11-932): 0: 586: 16.38		SYNJ1_RAT (246-575): 3.38e-15: 81.2: 14.67