HitPredict

Interactor 1: AP2A2 (O94973)
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)
Gene: AP2A2

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	9723620
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 939 Hs			1 576
+	Rn
		312072 AP2A2_RAT (1-939): 0: 889: 97.02		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Rn
		312080 Q66HM2_RAT (1-939): 0: 886: 96.28		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Hs
		323715 AP2A2_HUMAN (1-939): 0: 884: 100.00		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Rn
		93079 D3ZUY8_RAT (1-939): 0: 836: 81.17		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Hs
		344689 AP2A1_HUMAN (1-939): 0: 832: 78.47		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Hs
		344839 AP2A1_HUMAN (1-939): 0: 832: 78.47		EPN1_HUMAN (1-576): 7.54e-90: 290: 100.00
+	Dm
		1019496 AP2A_DROME (3-939): 0: 819: 69.50		Q7KU90_DROME (1-571): 7.17e-58: 209: 31.51
+	Hs
		215887 AP2A2_HUMAN (1-939): 0: 884: 100.00		SYNJ1_HUMAN (246-573): 8.4e-20: 96.3: 14.11
+	Rn
		1224312 Q66HM2_RAT (1-939): 0: 886: 96.28		SYNJ1_RAT (246-575): 3.38e-15: 81.2: 14.67
+	At
		1320402 AP2A1_ARATH (8-939): 0: 711: 37.23		EPN1_ARATH (2-453): 5.34e-71: 239: 21.26
+	Hs
		215889 AP2A1_HUMAN (1-939): 0: 832: 78.47		SYNJ1_HUMAN (246-573): 8.4e-20: 96.3: 14.11
+	Hs
		225811 AP1G1_HUMAN (1-811): 0: 616: 25.12		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Rn
		312074 AP2B1_RAT (36-933): 0: 607: 16.62		EPN1_RAT (1-576): 4.67e-91: 293: 94.27
+	Hs
		988964 AP2B1_HUMAN (36-933): 0: 607: 16.62		EPN4_HUMAN (3-561): 2.38e-89: 290: 24.14
+	Hs
		989181 AP2B1_HUMAN (36-933): 0: 607: 16.62		EPN1_HUMAN (1-576): 7.54e-90: 290: 100.00
+	At
		1227892 AP2A1_ARATH (8-939): 0: 711: 37.23		EPN2_ARATH (2-574): 1.97e-39: 156: 21.89
+	Rn
		986891 AP2B1_RAT (36-933): 0: 607: 16.62		EPN2_RAT (1-562): 2.37e-67: 231: 42.44
+	Sc
		792680 AP2A_YEAST (10-937): 0: 606: 25.44		ENT1_YEAST (3-228): 7.21e-62: 212: 36.73
+	Hs
		329443 AP2B1_HUMAN (36-933): 0: 607: 16.62		EPN2_HUMAN (1-566): 1.15e-53: 194: 38.02
+	Hs
		215915 AP2B1_HUMAN (36-933): 0: 607: 16.62		SYNJ1_HUMAN (246-573): 8.4e-20: 96.3: 14.11