HitPredict

Interactor 1: FMR1 (Q06787)
Fragile X messenger ribonucleoprotein 1 (Fragile X messenger ribonucleoprotein) (FMRP) (Protein FMR-1)
Gene: FMR1

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	33711283, 35915203
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 632 Hs			1 2610
+	Hs
		843958 FXR1_HUMAN (1-334): 0: 604: 73.95		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		844282 FXR2_HUMAN (268-525): 3.17e-50: 186: 30.56		HECD1_HUMAN (1-2610): 0: 2419: 100.00
+	Hs
		304136 FMR1_HUMAN (1-632): 0: 1106: 100.00		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		125399 FMR1_HUMAN (1-632): 0: 1106: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Mm
		729424 FMR1_MOUSE (1-632): 0: 1063: 93.99		NEDD4_MOUSE (2258-2608): 9.66e-121: 407: 19.89
+	Mm
		729556 FMR1_MOUSE (1-632): 0: 1063: 93.99		ITCH_MOUSE (2234-2608): 1.69e-118: 400: 22.40
+	Mm
		808366 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		NEDD4_MOUSE (2258-2608): 9.66e-121: 407: 19.89
+	Mm
		1207058 Q8BPK8_MOUSE (1-357): 0: 688: 97.76		ITCH_MOUSE (2234-2608): 1.69e-118: 400: 22.40
+	Mm
		808357 FXR1_MOUSE (1-334): 0: 596: 73.65		NEDD4_MOUSE (2258-2608): 9.66e-121: 407: 19.89
+	Hs
		843917 FXR1_HUMAN (1-334): 0: 604: 73.95		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125254 FXR1_HUMAN (1-334): 0: 604: 73.95		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		125255 FXR2_HUMAN (268-525): 3.17e-50: 186: 30.56		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86