HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: MRTFA (Q969V6)
Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)
Gene: MRTFA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~RPEL
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 931
+	Hs
		953019 ACTB_HUMAN (1-375): 0: 604: 98.93		MRTFA_HUMAN (1-931): 3.3e-102: 342: 100.00
+	Hs
		995750 ACTC_HUMAN (2-375): 0: 594: 94.39		MRTFA_HUMAN (1-931): 3.3e-102: 342: 100.00
+	Hs
		590291 ACTBL_HUMAN (2-375): 0: 734: 91.44		MUC1_HUMAN (119-913): 4.25e-52: 200: 11.46
+	Hs
		1030652 ACTBL_HUMAN (2-375): 0: 734: 91.44		ANK2_HUMAN (13-906): 1.72e-14: 80.8: 11.55
+	Hs
		1200982 ACTBL_HUMAN (2-375): 0: 734: 91.44		SRCAP_HUMAN (235-912): 1.87e-11: 70.7: 12.55
+	Hs
		953176 ACTB_HUMAN (1-375): 0: 604: 98.93		MRTFB_HUMAN (1-928): 7.06e-52: 199: 32.56
+	Hs
		993379 ACTG_HUMAN (1-375): 0: 604: 100.00		MRTFB_HUMAN (1-928): 7.06e-52: 199: 32.56
+	Hs
		590266 ACTA_HUMAN (2-375): 0: 594: 94.39		MUC1_HUMAN (119-913): 4.25e-52: 200: 11.46
+	Hs
		995592 ACTC_HUMAN (2-375): 0: 594: 94.39		MDC1_HUMAN (5-909): 2.95e-30: 131: 8.46
+	Hs
		952780 ACTB_HUMAN (1-375): 0: 604: 98.93		EP300_HUMAN (252-864): 4.31e-26: 118: 14.00
+	Hs
		977683 ACTA_HUMAN (2-375): 0: 594: 94.39		EP300_HUMAN (252-864): 4.31e-26: 118: 14.00
+	Hs
		996441 ACTS_HUMAN (2-375): 0: 594: 93.85		EP300_HUMAN (252-864): 4.31e-26: 118: 14.00
+	Hs
		952752 ACTB_HUMAN (1-375): 0: 604: 98.93		ANK2_HUMAN (13-906): 1.72e-14: 80.8: 11.55
+	Hs
		952739 ACTB_HUMAN (1-375): 0: 604: 98.93		MAP1A_HUMAN (68-870): 6.16e-12: 72.4: 9.86
+	Hs
		952913 ACTB_HUMAN (1-375): 0: 604: 98.93		SRCAP_HUMAN (235-912): 1.87e-11: 70.7: 12.55
+	Hs
		993223 ACTG_HUMAN (1-375): 0: 604: 100.00		SRCAP_HUMAN (235-912): 1.87e-11: 70.7: 12.55
+	Hs
		952822 ACTB_HUMAN (1-375): 0: 604: 98.93		NCOA6_HUMAN (184-931): 3.65e-09: 63.1: 11.05
+	Hs
		215916 ACTC_HUMAN (2-375): 0: 594: 94.39		SYNJ1_HUMAN (137-582): 4.42e-12: 72.4: 9.17
+	Hs
		995656 ACTC_HUMAN (2-375): 0: 594: 94.39		SRCAP_HUMAN (235-912): 1.87e-11: 70.7: 12.55
+	Hs
		995654 ACTC_HUMAN (2-375): 0: 594: 94.39		LMTK1_HUMAN (150-823): 1.81e-10: 67.1: 12.62