HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: TWF1 (Q12792)
Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
Gene: TWF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.44 1.00 0.665

The method score is based on:

Property Details
Experiments 30890647
Identification Methods affinity chromatography technology, proximity labelling technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Actin~Cofilin_ADF
Common GO terms GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005884 - actin filament
GO:0005925 - focal adhesion
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 377
Hs

1 350
+ Hs
+ Hs
+ Hs
+ Sp
+ At
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025