Interactor 1: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Interactor 2: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.942

The method score is based on:

Property Details
Experiments 29643511, 27182664, 25752577, 25723849, 26949039, 9575161
Identification Methods pull down, enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains HECT~UQ_con
Common GO terms GO:0000209 - protein polyubiquitination
GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 154
Hs

1 1083
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025