HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: CRTC2 (Q53ET0)
CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)
Gene: CRTC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17476304
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2414 Hs			1 693
+	Hs
		998823 EP300_HUMAN (1-2414): 0: 1113: 100.00		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Hs
		554303 EP300_HUMAN (1-2414): 0: 1113: 100.00		MUC1_HUMAN (180-680): 1.42e-24: 111: 12.70
+	Hs
		998826 EP300_HUMAN (1-2414): 0: 1113: 100.00		SRCAP_HUMAN (11-552): 9.96e-11: 67.6: 9.25
+	Dm
		115975 M9PH39_DROME (430-2323): 0: 769: 36.52		RPB1_DROME (186-535): 6.15e-14: 78: 12.50
+	Hs
		1120143 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		CRTC2_HUMAN (1-693): 1.02e-75: 259: 100.00
+	Hs
		1164809 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		ANR11_HUMAN (125-665): 2.18e-23: 108: 13.68
+	Hs
		1017367 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		BPTF_HUMAN (25-490): 1.63e-29: 128: 14.02
+	Hs
		1300957 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81
+	Hs
		631413 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		BPTF_HUMAN (25-490): 1.63e-29: 128: 14.02
+	Hs
		1017300 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		BPTF_HUMAN (25-490): 1.63e-29: 128: 14.02
+	Hs
		554259 MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23		MUC1_HUMAN (180-680): 1.42e-24: 111: 12.70
+	Hs
		1164929 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Mm
		1351630 PCLO_MOUSE (1988-2414): 9.66e-13: 76.7: 11.24		PCLO_MOUSE (230-693): 2.57e-18: 92.2: 10.54
+	Hs
		297832 BRWD3_HUMAN (1006-1157): 1.89e-10: 68.9: 27.93		K0754_HUMAN (6-347): 2.26e-17: 89.1: 12.28
+	Dm
		113976 M9PB30_DROME (5-444): 3.69e-13: 78.3: 7.05		M9PB30_DROME (1-376): 5.96e-10: 65.3: 11.08
+	Hs
		1199209 PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92		CHD7_HUMAN (6-494): 5.34e-12: 71.8: 9.31
+	Hs
		1300971 CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81
+	Hs
		1170076 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		SRCAP_HUMAN (11-552): 9.96e-11: 67.6: 9.25