HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: AUTS2 (Q8WXX7)
Autism susceptibility gene 2 protein
Gene: AUTS2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	25519132, 34637754
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2414 Hs			1 1259
+	Mm
		377 EP300_MOUSE (1-2414): 0: 1090: 93.01		AUTS2_MOUSE (1-1259): 7.09e-133: 440: 90.25
+	Hs
		554303 EP300_HUMAN (1-2414): 0: 1113: 100.00		MUC1_HUMAN (21-960): 4.41e-54: 209: 12.26
+	Mm
		70930 EP300_MOUSE (1-2414): 0: 1090: 93.01		Q6PED7_MOUSE (637-1259): 1.68e-63: 230: 92.01
+	Hs
		998713 EP300_HUMAN (1-2414): 0: 1113: 100.00		NCOA6_HUMAN (63-1250): 4.76e-13: 76.3: 10.27
+	Hs
		999163 EP300_HUMAN (1-2414): 0: 1113: 100.00		RERE_HUMAN (10-900): 6.62e-13: 75.9: 9.42
+	Hs
		998710 EP300_HUMAN (1-2414): 0: 1113: 100.00		MDC1_HUMAN (700-1257): 7.36e-10: 65.9: 8.20
+	Hs
		998826 EP300_HUMAN (1-2414): 0: 1113: 100.00		SRCAP_HUMAN (630-1257): 7.98e-09: 62.8: 10.00
+	Hs
		631529 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		AUTS2_HUMAN (1-1259): 1.57e-142: 466: 100.00
+	Hs
		631600 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03
+	Hs
		554259 MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23		MUC1_HUMAN (21-960): 4.41e-54: 209: 12.26
+	Hs
		1300957 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34
+	Hs
		1057027 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		MDC1_HUMAN (700-1257): 7.36e-10: 65.9: 8.20
+	Mm
		1351630 PCLO_MOUSE (1988-2414): 9.66e-13: 76.7: 11.24		PCLO_MOUSE (332-1258): 3.03e-28: 126: 8.82
+	Hs
		631425 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		MDC1_HUMAN (700-1257): 7.36e-10: 65.9: 8.20
+	Hs
		1056838 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		MDC1_HUMAN (700-1257): 7.36e-10: 65.9: 8.20
+	Dm
		113976 M9PB30_DROME (5-444): 3.69e-13: 78.3: 7.05		M9PB30_DROME (775-1258): 5.99e-12: 73.2: 11.96
+	Hs
		1262830 PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86		RERE_HUMAN (10-900): 6.62e-13: 75.9: 9.42
+	Hs
		257668 PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86		ANR17_HUMAN (242-849): 1.24e-11: 71.9: 10.62
+	Hs
		1300971 CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34
+	Hs
		1056827 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		MDC1_HUMAN (700-1257): 7.36e-10: 65.9: 8.20