HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: RBP56 (Q92804)
TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)
Gene: TAF15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	30110629, 33742100, 18509338
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2414 Hs			1 592
+	Hs
		967131 EP300_HUMAN (1-2414): 0: 1113: 100.00		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		726775 EP300_HUMAN (1-2414): 0: 1113: 100.00		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		967540 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		1271215 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		RBP56_HUMAN (1-394): 3.45e-37: 148: 100.00
+	Hs
		967517 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		1049681 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		EIF3A_HUMAN (314-591): 5.41e-22: 103: 18.21
+	Hs
		518057 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		CO6A3_HUMAN (3-229): 4.65e-22: 103: 10.46
+	Hs
		967421 BRD8_HUMAN (965-1183): 9.91e-16: 86: 19.18		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		967173 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		967541 PCLO_HUMAN (533-1087): 8.45e-12: 73.6: 11.83		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		967313 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		726817 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		726907 PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		726964 CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		517999 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		CO6A2_HUMAN (69-393): 1.2e-20: 98.8: 11.04