Protein: SMO
Protein smoothened (dSMO) (SMOH) (Smooth)

Gene: SMO
Organism: Drosophila melanogaster
Interactions: 40
UniProt ID: P91682

Gene Ontology (top 5):
GO:0001745 - compound eye morphogenesis
GO:0001746 - Bolwig's organ morphogenesis
GO:0002385 - mucosal immune response
GO:0004930 - G protein-coupled receptor activity
GO:0005113 - patched binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1019393

SMO
Protein smoothened

6

13

Small-scale

0.957

High

195763

COS
Kinesin-like protein costa

16

0

Small-scale

0.729

High

661843

FUSED
Serine/threonine-protein kinase fused

9

0

Small-scale

0.719

High

553476

KAPC1
cAMP-dependent protein kinase catalytic subunit 1

4

0

Small-scale

0.661

High

624300

CI
Transcriptional activator cubitus interruptus

3

1

Small-scale

0.640

High

746380

GPRK2
G protein-coupled receptor kinase 2

2

1

Small-scale

0.634

High

1019406

Q9VDD8
Ubiquitin carboxyl-terminal hydrolase

4

2

Small-scale

0.630

High

1019402

Q9V393
Kurtz arrestin

4

4

Small-scale

0.623

High

615053

PTC
Protein patched

2

5

Small-scale

0.584

High

1019403

SMUF1
E3 ubiquitin-protein ligase Smurf1

2

2

Small-scale

0.533

High

1019397

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.486

High

304783

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

9

Small-scale

0.479

High

684600

GBB1
Guanine nucleotide-binding protein subunit beta-1

1

2

Small-scale

0.479

High

873563

PP1B
Serine/threonine-protein phosphatase beta isoform

1

12

Small-scale

0.479

High

1019398

Q4AB31
non-specific serine/threonine protein kinase

1

1

Small-scale

0.479

High

356322

O97102
Small ubiquitin-related modifier

1

0

Small-scale

0.458

High

1019405

Q9VC05
Oxysterol-binding protein

1

0

Small-scale

0.458

High

1019407

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

Small-scale

0.458

High

121771

M9PGG8
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

509793

UBIQP
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

Small-scale

0.437

High

559030

PP12
Serine/threonine-protein phosphatase alpha-2 isoform

1

12

Small-scale

0.437

High

583664

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

Small-scale

0.437

High

661922

PP2A
Serine/threonine-protein phosphatase PP2A

1

8

Small-scale

0.437

High

873518

PP11
Serine/threonine-protein phosphatase alpha-1 isoform

1

12

Small-scale

0.437

High

1019395

PP13
Serine/threonine-protein phosphatase alpha-3 isoform

1

12

Small-scale

0.437

High

1019399

Q5BI50
Cullin-4A

1

2

Small-scale

0.437

High

1019409

Q9VYQ3
Ubiquitin carboxyl-terminal hydrolase

1

1

Small-scale

0.437

High

1019410

Q9W418
GH17761p

1

1

Small-scale

0.437

High

1019412

Q9XZ61
Ubiquitin carboxyl-terminal hydrolase

1

1

Small-scale

0.437

High

262761

TENM
Teneurin-m

1

0

High-throughput

0.426

High

1019400

Q8SXJ8
RE19335p

1

1

High-throughput

0.417

High

1019394

HH
Protein hedgehog

1

0

High-throughput

0.365

High

1019401

HRS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

Small-scale

0.305

High

1019408

Q9VWK5
GH15225p

2

0

Small-scale

0.305

High

1019396

SMG
Protein Smaug

1

0

Small-scale

0.288

High

304609

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.265

Low

620694

SXL
Protein sex-lethal

1

0

Small-scale

0.249

Low

1019404

Q9VB23
Serine/threonine protein phosphatase 2A regulatory subunit

1

0

Small-scale

0.249

Low

1019411

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025