Protein: IPYR2
Inorganic pyrophosphatase 2, mitochondrial (EC 3.6.1.1) (Pyrophosphatase SID6-306) (Pyrophosphate phospho-hydrolase 2) (PPase 2)

Gene: IPYR2, PPA2
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9H2U2

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004427 - inorganic diphosphate phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

803231

IF2M
Translation initiation factor IF-2, mitochondrial

4

3

High-throughput

0.694

High

1329699

ACS2L
Acetyl-coenzyme A synthetase 2-like, mitochondrial

3

1

High-throughput

0.667

High

1086780

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

4

0

High-throughput

0.657

High

1137435

LYRM7
Complex III assembly factor LYRM7

3

0

High-throughput

0.638

High

1286916

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

2

1

High-throughput

0.611

High

1313565

MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

2

0

High-throughput

0.585

High

1329702

NPS3A
Protein NipSnap homolog 3A

2

0

High-throughput

0.585

High

1130581

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.571

High

262962

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

347874

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.521

High

602583

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.513

High

1136736

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

1

0

High-throughput

0.513

High

1329695

KDM4C
Lysine-specific demethylase 4C

1

2

High-throughput

0.489

High

1329706

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.489

High

265034

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

270121

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

500108

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

827584

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

1020556

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

1185368

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

1201907

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.479

High

1241802

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

1

High-throughput

0.479

High

1282833

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1297461

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1301136

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1329703

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

59303

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

129834

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

300822

GLSK
Glutaminase kidney isoform, mitochondrial

1

0

High-throughput

0.458

High

398402

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.458

High

440729

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

681592

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

777735

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

789988

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

799359

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

832938

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

959042

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

981421

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

990303

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1018049

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1033815

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1045860

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1068081

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1128247

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1152968

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1253767

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1284524

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1289124

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1314200

TR61B
tRNA

1

0

High-throughput

0.458

High

1315016

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1329476

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1329696

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1329698

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1329700

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1329701

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1282037

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.439

High

101174

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

329945

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

721420

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

780090

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

909109

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

951329

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.437

High

1036072

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

1169500

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.437

High

1171680

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1176270

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

1302837

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

1319306

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.437

High

1329704

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1329705

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.437

High

1329707

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

378169

PRIO
Major prion protein

1

1

High-throughput

0.407

High

559489

H13
Histone H1.3

3

0

High-throughput

0.347

High

1191960

ARPIN
Arpin

3

0

High-throughput

0.347

High

1329697

SYNCI
Syncoilin

2

0

High-throughput

0.328

High

256676

CLU
Clustered mitochondria protein homolog

2

0

High-throughput

0.318

High

791974

HD
Huntingtin

2

0

High-throughput

0.311

High

308020

ZWINT
ZW10 interactor

1

0

High-throughput

0.279

Low

344012

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.279

Low

147559

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.269

Low

1309365

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

196346

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.249

Low

295249

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

324616

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.249

Low

847894

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.249

Low

1184331

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1284236

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024