Protein: THOC2
THO complex subunit 2 (Tho2) (hTREX120)

Gene: THOC2
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q8NI27

Gene Ontology (top 5):
GO:0000346 - transcription export complex
GO:0000347 - THO complex
GO:0000445 - THO complex part of transcription export complex
GO:0000902 - cell morphogenesis
GO:0001824 - blastocyst development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1046111

DX39B
Spliceosome RNA helicase DDX39B

8

12

Small-scale

0.970

High

1246348

THOC1
THO complex subunit 1

8

3

Small-scale

0.966

High

1246350

THOC3
THO complex subunit 3

6

14

Small-scale

0.947

High

1202870

THOC6
THO complex subunit 6 homolog

4

20

Small-scale

0.881

High

1151833

THOC7
THO complex subunit 7 homolog

3

0

Small-scale

0.803

High

1201103

THOC4
THO complex subunit 4

6

8

Small-scale

0.735

High

1045263

THOC5
THO complex subunit 5 homolog

6

2

Small-scale

0.722

High

117185

DX39A
ATP-dependent RNA helicase DDX39A

1

13

High-throughput

0.691

High

757690

IF4A3
Eukaryotic initiation factor 4A-III

1

11

High-throughput

0.691

High

994257

DHX9
ATP-dependent RNA helicase A

1

7

High-throughput

0.691

High

1120403

NCBP3
Nuclear cap-binding protein subunit 3

4

2

High-throughput

0.678

High

998125

NCBP1
Nuclear cap-binding protein subunit 1

3

3

Small-scale

0.633

High

1246351

WDR90
WD repeat-containing protein 90

1

7

High-throughput

0.618

High

268185

EED
Polycomb protein EED

1

20

High-throughput

0.618

High

1246362

DDX23
Probable ATP-dependent RNA helicase DDX23

1

11

High-throughput

0.618

High

856742

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

228115

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

322902

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

13

High-throughput

0.584

High

347385

MYC
Myc proto-oncogene protein

2

19

High-throughput

0.584

High

432079

HS90A
Heat shock protein HSP 90-alpha

2

4

High-throughput

0.584

High

438371

HS90B
Heat shock protein HSP 90-beta

2

4

High-throughput

0.584

High

553239

RFA2
Replication protein A 32 kDa subunit

2

9

High-throughput

0.584

High

651741

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

8

High-throughput

0.584

High

720963

RFA3
Replication protein A 14 kDa subunit

2

8

High-throughput

0.584

High

1246391

CHTOP
Chromatin target of PRMT1 protein

2

0

Small-scale

0.576

High

1246384

DDX41
Probable ATP-dependent RNA helicase DDX41

1

4

High-throughput

0.575

High

256548

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

595322

LMNB1
Lamin-B1

1

4

High-throughput

0.536

High

869688

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.536

High

877321

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

13

High-throughput

0.536

High

948894

SARNP
SAP domain-containing ribonucleoprotein

1

2

High-throughput

0.536

High

1039007

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

2

High-throughput

0.536

High

1060837

IMB1
Importin subunit beta-1

1

4

High-throughput

0.536

High

1136020

RNH2B
Ribonuclease H2 subunit B

1

1

High-throughput

0.536

High

1139406

ECM29
Proteasome adapter and scaffold protein ECM29

1

3

High-throughput

0.536

High

1148681

VIR
Protein virilizer homolog

1

2

High-throughput

0.536

High

1238414

CS047
Uncharacterized protein C19orf47

1

1

High-throughput

0.536

High

1246357

CTIP
DNA endonuclease RBBP8

1

1

High-throughput

0.536

High

1246365

PDIP3
Polymerase delta-interacting protein 3

1

5

High-throughput

0.536

High

1246370

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.536

High

1246373

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.536

High

1246378

BCLF1
Bcl-2-associated transcription factor 1

1

10

High-throughput

0.536

High

1246385

ZN346
Zinc finger protein 346

1

1

High-throughput

0.536

High

1246387

KMT2B
Histone-lysine N-methyltransferase 2B

1

18

High-throughput

0.536

High

418479

NPM
Nucleophosmin

1

1

High-throughput

0.515

High

1030168

STX3
Syntaxin-3

1

0

High-throughput

0.513

High

1246353

UIF
UAP56-interacting factor

1

0

High-throughput

0.513

High

1246379

CRIPT
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.513

High

890758

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

High-throughput

0.501

High

1246344

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

216949

KIF1C
Kinesin-like protein KIF1C

1

5

High-throughput

0.489

High

231641

KIF1B
Kinesin-like protein KIF1B

1

5

High-throughput

0.489

High

321297

TBCD8
TBC1 domain family member 8

1

2

High-throughput

0.489

High

581797

VCAM1
Vascular cell adhesion protein 1

1

3

High-throughput

0.489

High

816333

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

3

High-throughput

0.489

High

843807

FXR1
RNA-binding protein FXR1

1

11

High-throughput

0.489

High

972232

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

8

High-throughput

0.489

High

1040940

MTMR3
Myotubularin-related protein 3

1

1

High-throughput

0.489

High

1067542

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

1246340

TM131
Transmembrane protein 131

1

6

High-throughput

0.489

High

1246359

AKAP9
A-kinase anchor protein 9

1

10

High-throughput

0.489

High

1246360

CAB45
45 kDa calcium-binding protein

1

3

High-throughput

0.489

High

1246369

PKHF2
Pleckstrin homology domain-containing family F member 2

1

5

High-throughput

0.489

High

122891

MEN1
Menin

1

6

High-throughput

0.479

High

149078

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.479

High

233553

NUPR1
Nuclear protein 1

1

4

High-throughput

0.479

High

244681

BRD4
Bromodomain-containing protein 4

1

15

High-throughput

0.479

High

308907

KI20A
Kinesin-like protein KIF20A

1

13

High-throughput

0.479

High

379635

MYCN
N-myc proto-oncogene protein

1

19

High-throughput

0.479

High

385196

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

387148

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

442324

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

16

High-throughput

0.479

High

523889

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.479

High

652925

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

668842

PML
Protein PML

1

6

High-throughput

0.479

High

726945

FUS
RNA-binding protein FUS

1

10

High-throughput

0.479

High

808785

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

824202

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

13

High-throughput

0.479

High

917626

H4
Histone H4

1

11

High-throughput

0.479

High

929227

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.479

High

941197

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

944864

RED1
Double-stranded RNA-specific editase 1

1

13

High-throughput

0.479

High

959553

VIGLN
Vigilin

1

12

High-throughput

0.479

High

963860

SET
Protein SET

1

2

High-throughput

0.479

High

969871

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

974613

MECOM
Histone-lysine N-methyltransferase MECOM

1

5

High-throughput

0.479

High

1019032

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

1026091

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

9

High-throughput

0.479

High

1035907

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1042087

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1063504

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1063965

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

1162357

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

3

High-throughput

0.479

High

1200506

NAA40
N-alpha-acetyltransferase 40

1

7

High-throughput

0.479

High

1201552

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.479

High

1221585

SMC5
Structural maintenance of chromosomes protein 5

1

18

High-throughput

0.479

High

1246336

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1246342

RBP56
TATA-binding protein-associated factor 2N

1

6

High-throughput

0.479

High

1246346

FUBP1
Far upstream element-binding protein 1

1

12

High-throughput

0.479

High

1246347

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1246354

CIC
Protein capicua homolog

1

13

High-throughput

0.479

High

1246355

RING2
E3 ubiquitin-protein ligase RING2

1

14

High-throughput

0.479

High

1246356

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

10

High-throughput

0.479

High

1246364

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

1246366

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.479

High

1246371

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.479

High

1246372

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

1246374

ANLN
Anillin

1

7

High-throughput

0.479

High

1246375

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.479

High

1246376

AATF
Protein AATF

1

4

High-throughput

0.479

High

1246377

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

7

High-throughput

0.479

High

1246383

ZRAN1
Ubiquitin thioesterase ZRANB1

1

16

High-throughput

0.479

High

1246386

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.479

High

1246388

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

1

High-throughput

0.479

High

1246389

ASF1A
Histone chaperone ASF1A

1

4

High-throughput

0.479

High

92363

E9PB61
Aly/REF export factor

1

9

High-throughput

0.445

High

321136

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.445

High

402266

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

1039704

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.445

High

1043978

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.445

High

1057550

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

5

High-throughput

0.445

High

1075699

SF01
Splicing factor 1

1

7

High-throughput

0.445

High

1130349

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1199022

PABP2
Polyadenylate-binding protein 2

1

10

High-throughput

0.445

High

1246382

NXF1
Nuclear RNA export factor 1

1

3

Small-scale

0.445

High

166750

CE290
Centrosomal protein of 290 kDa

1

10

High-throughput

0.437

High

255936

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.437

High

298670

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.437

High

374565

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.437

High

613265

ITA6
Integrin alpha-6

1

1

High-throughput

0.437

High

684897

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

770941

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.437

High

779770

CCNF
Cyclin-F

1

4

High-throughput

0.437

High

802667

CRK
Adapter molecule crk

1

12

High-throughput

0.437

High

908848

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.437

High

922634

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.437

High

926609

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.437

High

1061510

CUL7
Cullin-7

1

4

High-throughput

0.437

High

1067060

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.437

High

1170909

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.437

High

1188586

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.437

High

1239299

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.437

High

1246337

COG1
Conserved oligomeric Golgi complex subunit 1

1

1

High-throughput

0.437

High

1246339

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

4

High-throughput

0.437

High

1246363

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

4

High-throughput

0.437

High

1246367

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

1246380

RM27
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.437

High

1246352

CEP63
Centrosomal protein of 63 kDa

1

12

High-throughput

0.417

High

831509

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

63015

A6NHV6
non-specific serine/threonine protein kinase

1

9

High-throughput

0.407

High

90042

D6RAN8
Mitochondrial ribosomal protein L27

1

1

High-throughput

0.407

High

92374

E9PBL8
Conserved oligomeric Golgi complex subunit 1

1

1

High-throughput

0.407

High

200631

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

High-throughput

0.407

High

580145

K2C4
Keratin, type II cytoskeletal 4

1

1

High-throughput

0.407

High

1047171

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.407

High

1124563

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.407

High

1128599

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

2

High-throughput

0.407

High

1246338

Q8WVC2
40S ribosomal protein S21

1

1

High-throughput

0.407

High

328903

TOP3B
DNA topoisomerase 3-beta-1

2

0

High-throughput

0.318

High

173746

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.279

Low

392710

B3A2
Anion exchange protein 2

1

0

High-throughput

0.279

Low

800245

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

899990

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.279

Low

1075520

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.279

Low

1110513

GNPTA
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

1

0

High-throughput

0.279

Low

1135176

EEIG2
EEIG family member 2

1

0

High-throughput

0.279

Low

1221230

GPAM1
GPALPP motifs-containing protein 1

1

0

High-throughput

0.279

Low

1246341

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.279

Low

1246358

ATP5S
ATP synthase subunit s, mitochondrial

1

0

High-throughput

0.279

Low

1246361

RAMAC
RNA guanine-N7 methyltransferase activating subunit

1

0

High-throughput

0.279

Low

1246368

MOB1A
MOB kinase activator 1A

1

0

High-throughput

0.279

Low

1246390

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.279

Low

841474

BPL1
Biotin--protein ligase

1

0

High-throughput

0.269

Low

1151870

NADE
Glutamine-dependent NAD(+) synthetase

1

0

High-throughput

0.269

Low

279160

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low

429920

CATL1
Procathepsin L

1

0

High-throughput

0.249

Low

575795

VINC
Vinculin

1

0

High-throughput

0.249

Low

878044

TPD52
Tumor protein D52

1

0

High-throughput

0.249

Low

1246343

B2CL2
Bcl-2-like protein 2

1

0

High-throughput

0.249

Low

1246345

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.249

Low

1246349

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1246381

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024