Protein: PRTN3
Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)

Gene: PRTN3
Organism: Homo sapiens
Interactions: 90
UniProt ID: P24158

Gene Ontology (top 5):
GO:0004252 - serine-type endopeptidase activity
GO:0005102 - signaling receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

664032

ILEU
Leukocyte elastase inhibitor

2

20

Small-scale

0.799

High

664078

EGFL8
Epidermal growth factor-like protein 8

2

20

High-throughput

0.776

High

210711

KLK10
Kallikrein-10

1

17

High-throughput

0.691

High

299937

CBPD
Carboxypeptidase D

1

5

High-throughput

0.691

High

455634

KLK3
Prostate-specific antigen

1

15

High-throughput

0.691

High

520745

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

7

High-throughput

0.691

High

603747

ITA2
Integrin alpha-2

1

9

High-throughput

0.691

High

664031

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

7

High-throughput

0.691

High

664048

PRSS8
Prostasin

1

12

High-throughput

0.691

High

664063

AGRG6
Adhesion G-protein coupled receptor G6

1

9

High-throughput

0.691

High

664067

LRC17
Leucine-rich repeat-containing protein 17

1

8

High-throughput

0.691

High

369312

A1AT
Alpha-1-antitrypsin

1

20

Small-scale

0.647

High

539459

ITAM
Integrin alpha-M

1

9

Small-scale

0.618

High

664037

SC11A
Signal peptidase complex catalytic subunit SEC11A

2

3

High-throughput

0.601

High

664040

XIAP
E3 ubiquitin-protein ligase XIAP

2

10

High-throughput

0.601

High

664054

KLH22
Kelch-like protein 22

2

4

High-throughput

0.601

High

322582

FBX21
F-box only protein 21

2

0

High-throughput

0.576

High

663743

IL32
Interleukin-32

1

0

Small-scale

0.561

High

136596

MANBA
Beta-mannosidase

1

5

High-throughput

0.536

High

160997

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

High-throughput

0.536

High

255754

USO1
General vesicular transport factor p115

1

6

High-throughput

0.536

High

407984

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.536

High

457236

TBB5
Tubulin beta chain

1

20

High-throughput

0.536

High

534648

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.536

High

612036

ITB5
Integrin beta-5

1

6

High-throughput

0.536

High

648421

FGFR4
Fibroblast growth factor receptor 4

1

13

High-throughput

0.536

High

650055

FGFR3
Fibroblast growth factor receptor 3

1

15

High-throughput

0.536

High

664029

DCK
Deoxycytidine kinase

1

2

High-throughput

0.536

High

664033

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.536

High

664034

STAT3
Signal transducer and activator of transcription 3

1

3

High-throughput

0.536

High

664038

TBA4A
Tubulin alpha-4A chain

1

20

High-throughput

0.536

High

664042

BIRC2
Baculoviral IAP repeat-containing protein 2

1

7

High-throughput

0.536

High

664044

PUM1
Pumilio homolog 1

1

1

High-throughput

0.536

High

664046

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

3

High-throughput

0.536

High

664047

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

664050

QRIC1
Transcriptional regulator QRICH1

1

1

High-throughput

0.536

High

664052

TBB8
Tubulin beta-8 chain

1

20

High-throughput

0.536

High

664056

TGO1
Transport and Golgi organization protein 1 homolog

1

4

High-throughput

0.536

High

664058

LYPL1
Lysophospholipase-like protein 1

1

1

High-throughput

0.536

High

664060

POTEE
POTE ankyrin domain family member E

1

6

High-throughput

0.536

High

664062

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.536

High

664064

FRAS1
Extracellular matrix organizing protein FRAS1

1

20

High-throughput

0.536

High

664068

NLGN2
Neuroligin-2

1

1

High-throughput

0.536

High

664069

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.536

High

664074

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.536

High

664075

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

1

High-throughput

0.536

High

664080

ERP44
Endoplasmic reticulum resident protein 44

1

9

High-throughput

0.536

High

664082

TMM59
Transmembrane protein 59

1

1

High-throughput

0.536

High

664085

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

664087

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

5

High-throughput

0.536

High

664089

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

5

High-throughput

0.536

High

664090

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

20

High-throughput

0.536

High

664039

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.515

High

664035

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.513

High

664055

SPIN4
Spindlin-4

1

0

High-throughput

0.513

High

664084

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.513

High

664092

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.513

High

584614

ELN
Elastin

1

12

Small-scale

0.501

High

664030

PROP
Properdin

1

16

Small-scale

0.501

High

136479

GOLI4
Golgi integral membrane protein 4

1

4

High-throughput

0.489

High

664041

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.489

High

664045

SPCS2
Signal peptidase complex subunit 2

1

2

High-throughput

0.489

High

664049

ISX
Intestine-specific homeobox

1

2

High-throughput

0.489

High

664053

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

3

High-throughput

0.489

High

664057

TMM69
Transmembrane protein 69

1

1

High-throughput

0.489

High

664061

NFXL1
NF-X1-type zinc finger protein NFXL1

1

16

High-throughput

0.489

High

664065

ELOA2
Elongin-A2

1

4

High-throughput

0.489

High

664066

CA174
UPF0688 protein C1orf174

1

1

High-throughput

0.489

High

664072

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

6

High-throughput

0.489

High

664073

PF21B
PHD finger protein 21B

1

5

High-throughput

0.489

High

664076

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.489

High

664077

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

9

High-throughput

0.489

High

664079

TBA1C
Tubulin alpha-1C chain

1

20

High-throughput

0.489

High

664083

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

2

High-throughput

0.489

High

664086

CP343
Cytochrome P450 3A43

1

1

High-throughput

0.489

High

271902

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.479

High

390994

TRFL
Lactotransferrin

1

3

High-throughput

0.479

High

425708

PERM
Myeloperoxidase

1

1

High-throughput

0.479

High

664070

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

664036

CAMP
Cathelicidin antimicrobial peptide

1

2

Small-scale

0.445

High

272614

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

5

High-throughput

0.437

High

612874

EGR1
Early growth response protein 1

1

1

High-throughput

0.437

High

343135

CXL14
C-X-C motif chemokine 14

1

0

Small-scale

0.426

High

664043

IL18
Interleukin-18

1

0

Small-scale

0.426

High

664088

INT13
Integrator complex subunit 13

1

0

High-throughput

0.426

High

664051

TR16L
Tripartite motif-containing protein 16-like protein

1

6

High-throughput

0.407

High

664081

RSRP1
Arginine/serine-rich protein 1

1

4

High-throughput

0.407

High

664059

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.279

Low

664071

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

664091

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025