Protein: TPP2
Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II)

Gene: TPP2
Organism: Homo sapiens
Interactions: 128
UniProt ID: P29144

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004175 - endopeptidase activity
GO:0004177 - aminopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

709135

DOK3
Docking protein 3

4

1

High-throughput

0.691

High

446511

DPOLB
DNA polymerase beta

3

0

High-throughput

0.654

High

709139

CARME
Carnosine N-methyltransferase

3

0

High-throughput

0.638

High

709160

CHIA
Acidic mammalian chitinase

3

0

High-throughput

0.638

High

709166

DEN2D
DENN domain-containing protein 2D

3

0

High-throughput

0.638

High

488203

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

3

0

High-throughput

0.634

High

709147

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

1

High-throughput

0.628

High

709151

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

2

High-throughput

0.628

High

709097

TPP2
Tripeptidyl-peptidase 2

1

13

Small-scale

0.621

High

658850

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.618

High

709134

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.618

High

708924

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

709136

NAA40
N-alpha-acetyltransferase 40

2

0

High-throughput

0.602

High

709146

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

709111

NCALD
Neurocalcin-delta

2

2

High-throughput

0.601

High

709116

ECHP
Peroxisomal bifunctional enzyme

2

3

High-throughput

0.596

High

240831

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

709180

ZRAN1
Ubiquitin thioesterase ZRANB1

2

1

High-throughput

0.584

High

539865

RALB
Ras-related protein Ral-B

2

3

High-throughput

0.574

High

709120

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

1

High-throughput

0.571

High

709164

CAD19
Cadherin-19

2

2

High-throughput

0.558

High

463357

LYN
Tyrosine-protein kinase Lyn

2

0

High-throughput

0.547

High

709156

SCLT1
Sodium channel and clathrin linker 1

2

0

High-throughput

0.547

High

193506

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

2

High-throughput

0.536

High

239300

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

2

High-throughput

0.536

High

255386

SNX2
Sorting nexin-2

1

1

High-throughput

0.536

High

362822

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.536

High

543466

VDR
Vitamin D3 receptor

1

1

High-throughput

0.536

High

709109

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.536

High

709113

HPCA
Neuron-specific calcium-binding protein hippocalcin

1

2

High-throughput

0.536

High

709125

NTRK3
NT-3 growth factor receptor

1

1

High-throughput

0.536

High

709126

AAK1
AP2-associated protein kinase 1

1

3

High-throughput

0.536

High

709148

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

709149

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.536

High

709182

CILK1
Serine/threonine-protein kinase ICK

1

1

High-throughput

0.536

High

208186

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.513

High

290462

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

407039

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

611774

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

692655

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

709098

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

709105

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

709117

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

709121

ARHG7
Rho guanine nucleotide exchange factor 7

1

0

High-throughput

0.513

High

709138

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

0

High-throughput

0.513

High

709152

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.513

High

709158

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

709167

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

709171

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

709123

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

709128

ANR39
Ankyrin repeat domain-containing protein 39

1

2

High-throughput

0.489

High

709175

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.489

High

709183

NTNG1
Netrin-G1

1

2

High-throughput

0.489

High

709177

TBA8
Tubulin alpha-8 chain

1

1

High-throughput

0.481

High

413251

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

457248

TBB5
Tubulin beta chain

1

2

High-throughput

0.479

High

468099

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

694692

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

709108

ATX1
Ataxin-1

1

1

High-throughput

0.479

High

709114

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

709118

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

709124

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

709144

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

709165

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

709185

3BP1
SH3 domain-binding protein 1

1

1

High-throughput

0.479

High

709106

MTR1A
Melatonin receptor type 1A

1

1

High-throughput

0.464

High

709179

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

333944

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.458

High

587982

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

659364

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

667553

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

709099

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

709100

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

709101

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

709102

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

0

High-throughput

0.458

High

709104

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

709112

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

709122

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

709127

MIDN
Midnolin

1

0

High-throughput

0.458

High

709142

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

709143

THOC2
THO complex subunit 2

1

0

High-throughput

0.458

High

709145

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

709150

SPDLY
Protein Spindly

1

0

High-throughput

0.458

High

709162

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

709168

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

709169

RC3H2
Roquin-2

1

0

High-throughput

0.458

High

709173

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

142283

PEX7
Peroxisomal targeting signal 2 receptor

1

3

High-throughput

0.445

High

330051

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.445

High

709161

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

709174

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

379892

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

High-throughput

0.437

High

411417

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

709176

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

High-throughput

0.437

High

132907

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.426

High

354555

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

369159

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

529152

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

709107

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

211117

CTR4
Cationic amino acid transporter 4

1

3

High-throughput

0.407

High

709103

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

3

High-throughput

0.407

High

709115

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.407

High

709131

S39A4
Zinc transporter ZIP4

1

4

High-throughput

0.407

High

709132

S39A5
Zinc transporter ZIP5

1

4

High-throughput

0.407

High

709153

Q96KY9
CDH19 protein

1

2

High-throughput

0.407

High

709154

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

9

High-throughput

0.407

High

415993

CP1A1
Cytochrome P450 1A1

3

0

High-throughput

0.347

High

709140

KLH36
Kelch-like protein 36

2

0

High-throughput

0.328

High

709181

PCDGG
Protocadherin gamma-B4

2

0

High-throughput

0.328

High

709110

T2R31
Taste receptor type 2 member 31

1

0

High-throughput

0.279

Low

709129

TMM69
Transmembrane protein 69

1

0

High-throughput

0.279

Low

709130

SCYL2
SCY1-like protein 2

1

0

High-throughput

0.279

Low

709133

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

709141

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

709155

ZN75A
Zinc finger protein 75A

1

0

High-throughput

0.279

Low

709157

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

709159

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

709163

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

709170

WFDC1
WAP four-disulfide core domain protein 1

1

0

High-throughput

0.279

Low

709186

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.279

Low

105400

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

709178

TOM7
Mitochondrial import receptor subunit TOM7 homolog

1

0

High-throughput

0.249

Low

709184

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.249

Low

261094

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

709119

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

709137

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.232

Low

709172

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025