Protein: P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)

Gene: P4R3A, PPP4R3A
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q6IN85

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0006094 - gluconeogenesis
GO:0006974 - DNA damage response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

951993

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

12

5

Small-scale

0.761

High

1234626

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

7

2

Small-scale

0.753

High

1208181

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

4

1

High-throughput

0.694

High

1156518

CCDC6
Coiled-coil domain-containing protein 6

3

2

High-throughput

0.667

High

1234606

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

3

1

High-throughput

0.662

High

262527

MCE1
mRNA-capping enzyme

3

1

High-throughput

0.656

High

1234614

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

3

0

High-throughput

0.638

High

1144570

PTPA
Serine/threonine-protein phosphatase 2A activator

2

1

High-throughput

0.628

High

281981

MPPB
Mitochondrial-processing peptidase subunit beta

3

1

High-throughput

0.609

High

1131051

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

0

High-throughput

0.602

High

1234602

RHPN1
Rhophilin-1

2

0

High-throughput

0.602

High

1234604

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

1234636

PPME1
Protein phosphatase methylesterase 1

2

0

High-throughput

0.602

High

485658

RU2A
U2 small nuclear ribonucleoprotein A'

2

0

High-throughput

0.576

High

574323

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.576

High

69792

ZN785
Zinc finger protein 785

2

1

High-throughput

0.574

High

1234595

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

1234615

CRML
Protein cramped-like

2

1

High-throughput

0.574

High

194235

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.561

High

1117390

SPTN1
Spectrin alpha chain, non-erythrocytic 1

2

0

High-throughput

0.559

High

1234637

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

2

1

High-throughput

0.558

High

1234625

OCAD1
OCIA domain-containing protein 1

2

1

High-throughput

0.549

High

130508

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.536

High

849190

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.536

High

1148506

SF3B4
Splicing factor 3B subunit 4

1

1

High-throughput

0.536

High

1234608

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

High-throughput

0.536

High

1234630

EHD2
EH domain-containing protein 2

1

1

High-throughput

0.536

High

1234633

SF3B6
Splicing factor 3B subunit 6

1

1

High-throughput

0.536

High

886951

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.527

High

168706

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.518

High

1158117

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.518

High

595473

H15
Histone H1.5

1

3

High-throughput

0.515

High

1037208

H11
Histone H1.1

1

3

High-throughput

0.515

High

1161904

H31T
Histone H3.1t

1

2

High-throughput

0.515

High

208284

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.513

High

251773

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.513

High

285962

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.513

High

298397

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.513

High

326346

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.513

High

471863

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.513

High

643366

OSBP1
Oxysterol-binding protein 1

1

0

High-throughput

0.513

High

973949

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

974583

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

1037525

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1105312

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.513

High

1147914

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.513

High

1151257

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.513

High

1234603

CATIN
Splicing factor Cactin

1

0

High-throughput

0.513

High

1234610

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.513

High

1234617

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.513

High

1234618

NADAP
Kanadaptin

1

0

High-throughput

0.513

High

1234620

DOCK5
Dedicator of cytokinesis protein 5

1

0

High-throughput

0.513

High

1234622

SYF1
Pre-mRNA-splicing factor SYF1

1

0

High-throughput

0.513

High

1234629

ITSN2
Intersectin-2

1

0

High-throughput

0.513

High

1234631

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.513

High

1234632

GUAD
Guanine deaminase

1

0

High-throughput

0.513

High

443409

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.501

High

889438

CLK1
Dual specificity protein kinase CLK1

1

1

High-throughput

0.489

High

1211551

F120S
Uncharacterized protein FAM120AOS

1

1

High-throughput

0.489

High

1234599

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1234628

PA2GE
Group IIE secretory phospholipase A2

1

1

High-throughput

0.489

High

1209265

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.480

High

260083

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

588927

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

755735

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.479

High

881543

CDK8
Cyclin-dependent kinase 8

1

2

High-throughput

0.479

High

888129

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

998436

H31
Histone H3.1

1

2

High-throughput

0.479

High

1016945

H33
Histone H3.3

1

2

High-throughput

0.479

High

1096720

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1234600

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1234621

COG4
Conserved oligomeric Golgi complex subunit 4

1

1

High-throughput

0.479

High

596162

H12
Histone H1.2

1

3

High-throughput

0.470

High

1142795

PEA15
Astrocytic phosphoprotein PEA-15

1

0

Small-scale

0.460

High

243956

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.458

High

272259

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

372297

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

551099

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

558202

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

695713

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

719155

MPIP1
M-phase inducer phosphatase 1

1

0

High-throughput

0.458

High

731397

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

768431

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

791462

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

957418

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

1109821

HDAC1
Histone deacetylase 1

1

0

Small-scale

0.458

High

1113396

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1234596

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1234597

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1234605

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1234611

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1234616

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1234627

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1234635

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.458

High

412095

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

521748

H14
Histone H1.4

1

3

High-throughput

0.437

High

1234593

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1234612

UBX10
UBX domain-containing protein 10

1

1

High-throughput

0.437

High

1234619

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

400998

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

116959

J3KNI1
Conserved oligomeric Golgi complex subunit 4

1

1

High-throughput

0.407

High

516101

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

615182

PACA
Pituitary adenylate cyclase-activating polypeptide

2

0

High-throughput

0.328

High

878320

MRP
MARCKS-related protein

2

0

High-throughput

0.328

High

1234609

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.328

High

614697

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.279

Low

846759

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.279

Low

1200455

COBL1
Cordon-bleu protein-like 1

1

0

High-throughput

0.279

Low

1210838

DACT2
Dapper homolog 2

1

0

High-throughput

0.279

Low

1211099

TMM69
Transmembrane protein 69

1

0

High-throughput

0.279

Low

1234592

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

1234598

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

0

High-throughput

0.279

Low

1234601

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1234613

SIG12
Sialic acid-binding Ig-like lectin 12

1

0

High-throughput

0.279

Low

1234623

NECT3
Nectin-3

1

0

High-throughput

0.279

Low

1234624

FBX28
F-box only protein 28

1

0

High-throughput

0.279

Low

1234634

SKAP
Small kinetochore-associated protein

1

0

High-throughput

0.279

Low

1234638

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

1234594

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1234607

NELL1
Protein kinase C-binding protein NELL1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025