Protein: TOPK
Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)

Gene: TOPK, PBK
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q96KB5

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

322754

RHBT3
Rho-related BTB domain-containing protein 3

2

6

High-throughput

0.811

High

443477

CDK1
Cyclin-dependent kinase 1

2

4

Small-scale

0.806

High

1353585

ZN526
Zinc finger protein 526

2

0

High-throughput

0.742

High

1390143

MCRS1
Microspherule protein 1

2

0

High-throughput

0.742

High

1353323

DOK4
Docking protein 4

3

0

High-throughput

0.720

High

253376

JAK2
Tyrosine-protein kinase JAK2

1

5

High-throughput

0.691

High

274708

DNJB6
DnaJ homolog subfamily B member 6

1

4

High-throughput

0.691

High

946447

MTPN
Myotrophin

1

2

High-throughput

0.691

High

557430

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.687

High

1228910

MSL1
Male-specific lethal 1 homolog

5

0

High-throughput

0.686

High

125572

LEG9
Galectin-9

3

2

High-throughput

0.667

High

1185362

LEG9B
Galectin-9B

3

2

High-throughput

0.667

High

1395887

ZBT26
Zinc finger and BTB domain-containing protein 26

2

1

High-throughput

0.665

High

521412

ARAF
Serine/threonine-protein kinase A-Raf

1

18

Small-scale

0.656

High

1395890

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.656

High

414418

P53
Cellular tumor antigen p53

3

0

Small-scale

0.647

High

508452

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.647

High

1395889

CABP2
Calcium-binding protein 2

1

12

High-throughput

0.618

High

242605

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.618

High

625562

CSK22
Casein kinase II subunit alpha'

1

8

High-throughput

0.618

High

831256

CCNF
Cyclin-F

1

2

High-throughput

0.618

High

920197

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.618

High

573870

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.614

High

1327834

ARRD1
Arrestin domain-containing protein 1

3

1

High-throughput

0.609

High

1307240

TF2LY
Homeobox protein TGIF2LY

2

0

High-throughput

0.602

High

1358179

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

1394331

ZN414
Zinc finger protein 414

2

0

High-throughput

0.602

High

1395885

KAT8
Histone acetyltransferase KAT8

2

1

High-throughput

0.601

High

323529

TRI37
E3 ubiquitin-protein ligase TRIM37

3

7

High-throughput

0.597

High

401314

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.590

High

1389444

CHFR
E3 ubiquitin-protein ligase CHFR

1

0

Small-scale

0.586

High

889176

RBM25
RNA-binding protein 25

1

0

High-throughput

0.578

High

1328909

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.578

High

1209524

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

1395883

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

16

Small-scale

0.575

High

1348428

LNX1
E3 ubiquitin-protein ligase LNX

2

1

Small-scale

0.554

High

1255099

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.553

High

1091556

DLG1
Disks large homolog 1

1

0

Small-scale

0.549

High

223257

PRC1
Protein regulator of cytokinesis 1

1

0

Small-scale

0.537

High

951812

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.537

High

925966

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.536

High

1052901

HME1
Homeobox protein engrailed-1

1

1

High-throughput

0.536

High

1098584

GPS2
G protein pathway suppressor 2

1

0

High-throughput

0.518

High

591791

H2AX
Histone H2AX

1

0

Small-scale

0.513

High

617726

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

1229631

VIR
Protein virilizer homolog

1

0

High-throughput

0.513

High

1334787

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1369044

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1369957

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.513

High

935010

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.501

High

967915

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

Small-scale

0.501

High

280779

PR40A
Pre-mRNA-processing factor 40 homolog A

1

4

High-throughput

0.489

High

1383811

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.489

High

1395888

E41L5
Band 4.1-like protein 5

1

3

High-throughput

0.489

High

1395899

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

1395900

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.489

High

1395901

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

1207807

GASP1
G-protein coupled receptor-associated sorting protein 1

1

1

High-throughput

0.481

High

1395898

NSF1C
NSFL1 cofactor p47

1

0

Small-scale

0.480

High

315893

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

970933

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

1092915

STRN3
Striatin-3

1

2

High-throughput

0.479

High

1135777

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

1138518

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1395894

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1395897

TTF2
Transcription termination factor 2

1

2

High-throughput

0.479

High

162959

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

696233

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

1276647

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1395892

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

388082

MBP
Myelin basic protein

1

0

Small-scale

0.426

High

664934

CRHBP
Corticotropin-releasing factor-binding protein

1

0

High-throughput

0.426

High

1328605

MS3L1
MSL complex subunit 3

1

0

High-throughput

0.426

High

387874

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

1279015

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High

1316050

TRM2A
tRNA

2

0

High-throughput

0.328

High

1395893

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

366198

HPT
Haptoglobin

1

0

High-throughput

0.279

Low

572725

AK1A1
Aldo-keto reductase family 1 member A1

1

0

High-throughput

0.279

Low

699572

IL1R2
Interleukin-1 receptor type 2

1

0

High-throughput

0.279

Low

939520

FCGRN
IgG receptor FcRn large subunit p51

1

0

High-throughput

0.279

Low

1208231

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1211102

TMM69
Transmembrane protein 69

1

0

High-throughput

0.279

Low

1214362

SYT6
Synaptotagmin-6

1

0

High-throughput

0.279

Low

1326684

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.279

Low

1331783

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1339320

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.279

Low

1387145

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

1395886

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

1395891

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.279

Low

1395895

PGAP2
Acyltransferase PGAP2

1

0

High-throughput

0.279

Low

1395902

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

1395896

ATS5
A disintegrin and metalloproteinase with thrombospondin motifs 5

1

0

High-throughput

0.269

Low

1386860

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

1294984

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

Small-scale

0.261

Low

218636

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

418362

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

768913

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1383630

VOPP1
WW domain binding protein VOPP1

1

0

High-throughput

0.238

Low

379699

IGHA1
Immunoglobulin heavy constant alpha 1

1

0

High-throughput

0.232

Low

777626

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.232

Low

1395884

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

1395903

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025