Protein: M4K5
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)

Gene: M4K5, MAP4K5
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q9Y4K4

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1217605

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

4

17

High-throughput

0.896

High

339189

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

385785

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.754

High

924984

GRB2
Growth factor receptor-bound protein 2

9

20

Small-scale

0.753

High

442897

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.698

High

802792

CRK
Adapter molecule crk

4

20

Small-scale

0.691

High

802924

CRKL
Crk-like protein

3

20

Small-scale

0.664

High

1377884

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

17

Small-scale

0.647

High

1223299

ZN440
Zinc finger protein 440

1

5

High-throughput

0.625

High

442629

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.618

High

229162

PRKN
E3 ubiquitin-protein ligase parkin

1

19

High-throughput

0.618

High

318261

DIRA3
GTP-binding protein Di-Ras3

1

15

High-throughput

0.618

High

350725

RASK
GTPase KRas

1

20

High-throughput

0.618

High

412425

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.618

High

434099

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

508290

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

568844

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

17

High-throughput

0.618

High

793541

MUC18
Cell surface glycoprotein MUC18

1

10

High-throughput

0.618

High

872510

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.618

High

914488

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.618

High

916098

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

925763

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

940612

CXAR
Coxsackievirus and adenovirus receptor

1

6

High-throughput

0.618

High

968526

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

987310

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

20

High-throughput

0.618

High

1018207

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

17

High-throughput

0.618

High

1070479

RAB35
Ras-related protein Rab-35

1

16

High-throughput

0.618

High

1072635

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

1081657

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.618

High

1083064

CDC37
Hsp90 co-chaperone Cdc37

1

11

High-throughput

0.618

High

1172422

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1330457

DNJC5
DnaJ homolog subfamily C member 5

1

10

High-throughput

0.618

High

1331724

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1357277

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

1238607

EIF1A
Probable RNA-binding protein EIF1AD

2

0

High-throughput

0.585

High

1052362

SRC8
Src substrate cortactin

1

20

High-throughput

0.561

High

1272733

CSN5
COP9 signalosome complex subunit 5

1

10

High-throughput

0.541

High

1029365

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

2

High-throughput

0.536

High

1204120

CARM1
Histone-arginine methyltransferase CARM1

1

3

High-throughput

0.536

High

962488

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

7

High-throughput

0.515

High

537554

AK1A1
Aldo-keto reductase family 1 member A1

1

0

High-throughput

0.513

High

1065763

SETB1
Histone-lysine N-methyltransferase SETDB1

1

8

High-throughput

0.508

High

808337

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

High-throughput

0.501

High

1336133

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

20

Small-scale

0.501

High

348344

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

495644

THIO
Thioredoxin

1

2

High-throughput

0.479

High

557840

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

567345

CXA1
Gap junction alpha-1 protein

1

11

High-throughput

0.479

High

603270

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

2

High-throughput

0.479

High

666200

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

685801

PRDX2
Peroxiredoxin-2

1

5

High-throughput

0.479

High

825281

RL34
Large ribosomal subunit protein eL34

1

1

High-throughput

0.479

High

863149

PGTB2
Geranylgeranyl transferase type-2 subunit beta

1

1

High-throughput

0.479

High

905305

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

913207

ARF6
ADP-ribosylation factor 6

1

10

High-throughput

0.479

High

922033

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.479

High

922947

RL32
Large ribosomal subunit protein eL32

1

4

High-throughput

0.479

High

975133

CAV1
Caveolin-1

1

10

High-throughput

0.479

High

1021001

TRAF2
TNF receptor-associated factor 2

1

18

Small-scale

0.479

High

1084253

OCLN
Occludin

1

6

High-throughput

0.479

High

1152225

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.479

High

1163057

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

18

High-throughput

0.479

High

1304274

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.479

High

1307427

SH3G1
Endophilin-A2

1

20

High-throughput

0.479

High

1335147

CYBP
Calcyclin-binding protein

1

3

High-throughput

0.479

High

1354989

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1356043

DBNL
Drebrin-like protein

1

19

High-throughput

0.479

High

1377836

TCAF1
TRPM8 channel-associated factor 1

1

1

High-throughput

0.479

High

1377885

SNX9
Sorting nexin-9

1

6

High-throughput

0.479

High

560029

H12
Histone H1.2

1

4

High-throughput

0.470

High

63028

LR14B
Leucine-rich repeat-containing protein 14B

1

0

High-throughput

0.458

High

648945

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

63840

RTL1
Retrotransposon-like protein 1

1

1

High-throughput

0.437

High

132643

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

554148

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.437

High

652706

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.437

High

654932

CALX
Calnexin

1

1

High-throughput

0.437

High

721873

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

1283115

CK052
Uncharacterized protein C11orf52

1

6

High-throughput

0.437

High

1285971

PTER
Phosphotriesterase-related protein

1

1

High-throughput

0.437

High

1333056

CH033
UPF0488 protein C8orf33

1

2

High-throughput

0.437

High

1302941

CDRTF
CMT1A duplicated region transcript 15 protein

3

0

High-throughput

0.347

High

448866

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.279

Low

519113

PIP
Prolactin-inducible protein

1

0

High-throughput

0.249

Low

901633

LYSC
Lysozyme C

1

0

High-throughput

0.249

Low

1342282

BPIA1
BPI fold-containing family A member 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024