Protein: UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1)

Gene: UFD1
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q92890

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

934947

TERA
Transitional endoplasmic reticulum ATPase

29

8

Small-scale

0.769

High

1347626

NPL4
Nuclear protein localization protein 4 homolog

17

7

Small-scale

0.762

High

508371

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

5

Small-scale

0.726

High

1369999

FAF1
FAS-associated factor 1

5

9

Small-scale

0.709

High

1369998

AMFR
E3 ubiquitin-protein ligase AMFR

2

1

Small-scale

0.624

High

372747

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.613

High

320744

UBXN7
UBX domain-containing protein 7

2

7

High-throughput

0.611

High

1369973

FAF2
FAS-associated factor 2

2

8

High-throughput

0.611

High

1369986

UBXN6
UBX domain-containing protein 6

2

1

Small-scale

0.595

High

843832

HD
Huntingtin

2

0

High-throughput

0.594

High

1369972

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

2

0

Small-scale

0.585

High

1369975

VCIP1
Deubiquitinating protein VCPIP1

2

0

High-throughput

0.585

High

1369977

UBX10
UBX domain-containing protein 10

2

0

High-throughput

0.585

High

530167

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.576

High

1155622

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

High-throughput

0.576

High

1193267

SV2C
Synaptic vesicle glycoprotein 2C

2

2

High-throughput

0.574

High

1369994

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

1370000

NSF1C
NSFL1 cofactor p47

2

0

High-throughput

0.559

High

1369984

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.537

High

122635

UBXN8
UBX domain-containing protein 8

1

5

High-throughput

0.536

High

543248

UBL4A
Ubiquitin-like protein 4A

1

5

High-throughput

0.536

High

1046397

UBXN1
UBX domain-containing protein 1

1

6

High-throughput

0.536

High

415761

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

1209468

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.513

High

687844

SYVC
Valine--tRNA ligase

1

0

High-throughput

0.513

High

954723

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.513

High

1272410

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.513

High

1369992

EKI2
Ethanolamine kinase 2

1

0

High-throughput

0.513

High

1369997

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.508

High

221875

CHM2A
Charged multivesicular body protein 2a

1

0

Small-scale

0.504

High

406917

MAS
Proto-oncogene Mas

1

1

High-throughput

0.489

High

538798

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

1

High-throughput

0.489

High

720590

AA1R
Adenosine receptor A1

1

1

High-throughput

0.489

High

1316214

S22AF
Solute carrier family 22 member 15

1

1

High-throughput

0.489

High

1370003

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

1

High-throughput

0.489

High

414340

P53
Cellular tumor antigen p53

1

0

High-throughput

0.486

High

466585

TNR16
Tumor necrosis factor receptor superfamily member 16

1

0

High-throughput

0.486

High

839063

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.486

High

877462

MASP1
Mannan-binding lectin serine protease 1

1

0

High-throughput

0.486

High

1111956

SNX1
Sorting nexin-1

1

0

High-throughput

0.486

High

1150305

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.486

High

1308679

TIAM2
Rho guanine nucleotide exchange factor TIAM2

1

0

High-throughput

0.486

High

1338159

PPHLN
Periphilin-1

1

0

High-throughput

0.486

High

1098822

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

Small-scale

0.480

High

1370004

NUB1
NEDD8 ultimate buster 1

1

0

Small-scale

0.480

High

188699

BIRC5
Baculoviral IAP repeat-containing protein 5

1

1

Small-scale

0.479

High

425593

ISG15
Ubiquitin-like protein ISG15

1

6

Small-scale

0.479

High

683494

IKBA
NF-kappa-B inhibitor alpha

1

1

Small-scale

0.479

High

1152181

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.479

High

1218619

OTU1
Ubiquitin thioesterase OTU1

1

1

Small-scale

0.479

High

1229022

RNF43
E3 ubiquitin-protein ligase RNF43

1

2

High-throughput

0.479

High

1294225

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

1369974

RN185
E3 ubiquitin-protein ligase RNF185

1

1

High-throughput

0.479

High

1369985

ASPC1
Tether containing UBX domain for GLUT4

1

1

High-throughput

0.479

High

1369995

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

260253

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

315834

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

321322

ERLN2
Erlin-2

1

0

Small-scale

0.458

High

458456

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

481348

HMGB1
High mobility group protein B1

1

0

High-throughput

0.458

High

483943

HMOX1
Heme oxygenase 1

1

0

Small-scale

0.458

High

567459

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

568272

PLST
Plastin-3

1

0

High-throughput

0.458

High

570535

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.458

High

578694

GLNA
Glutamine synthetase

1

0

Small-scale

0.458

High

582602

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.458

High

605769

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

Small-scale

0.458

High

770780

PGH2
Prostaglandin G/H synthase 2

1

0

Small-scale

0.458

High

788978

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

831171

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

1007749

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.458

High

1041214

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

1067570

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

1098079

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

1101867

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

1121291

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1137433

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1138464

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1280380

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

1295519

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

1360791

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.458

High

1369976

IFT74
Intraflagellar transport protein 74 homolog

1

0

High-throughput

0.458

High

1369978

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1369983

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

1369989

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.458

High

1369996

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

1370001

POLH
DNA polymerase eta

1

0

Small-scale

0.458

High

1370002

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

1295463

S13A5
Na(+)/citrate cotransporter

1

1

High-throughput

0.445

High

1031482

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1129017

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

2

Small-scale

0.437

High

1142124

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.437

High

1254910

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

613422

VINC
Vinculin

1

0

High-throughput

0.426

High

664891

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

1194526

SL9C1
Solute carrier family 9 member C1

1

2

High-throughput

0.407

High

1215256

SL9C2
Sodium/hydrogen exchanger 11

1

2

High-throughput

0.407

High

1325643

SVOPL
Putative transporter SVOPL

1

2

High-throughput

0.407

High

1359754

S13A3
Na(+)/dicarboxylate cotransporter 3

1

1

High-throughput

0.407

High

1369982

SL9A7
Sodium/hydrogen exchanger 7

1

2

High-throughput

0.407

High

1369987

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

1

High-throughput

0.407

High

142147

NPT3
Sodium-dependent phosphate transport protein 3

2

0

High-throughput

0.328

High

1276265

ATG9A
Autophagy-related protein 9A

2

0

High-throughput

0.328

High

1333680

UBAC2
Ubiquitin-associated domain-containing protein 2

2

0

High-throughput

0.318

High

49809

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

665001

ERD21
ER lumen protein-retaining receptor 1

1

0

High-throughput

0.279

Low

1010510

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low

1207741

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

1308507

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

0

High-throughput

0.279

Low

1369980

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1369991

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.279

Low

956091

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.269

Low

361710

F13A
Coagulation factor XIII A chain

1

0

High-throughput

0.265

Low

369718

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.265

Low

892159

GRAK
Granzyme K

1

0

Small-scale

0.261

Low

48165

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.249

Low

178651

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.249

Low

353477

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

767481

RADI
Radixin

1

0

High-throughput

0.249

Low

1071249

TMM62
Transmembrane protein 62

1

0

High-throughput

0.249

Low

1347951

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.249

Low

1369981

KCNKG
Potassium channel subfamily K member 16

1

0

High-throughput

0.249

Low

1369990

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1369993

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

379558

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.238

Low

1199086

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low

1288434

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.232

Low

1316658

S38A6
Solute carrier family 38 member 6

1

0

High-throughput

0.232

Low

1335659

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1369979

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low

1369988

SC5A7
High affinity choline transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025