Protein: LRC14
Leucine-rich repeat-containing protein 14

Gene: LRC14, LRRC14
Organism: Homo sapiens
Interactions: 22
UniProt ID: Q15048

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019900 - kinase binding
GO:0032088 - negative regulation of NF-kappaB transcription factor activity
GO:0034122 - negative regulation of toll-like receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1139893

CSN6
COP9 signalosome complex subunit 6

4

2

High-throughput

0.691

High

1139895

CSN5
COP9 signalosome complex subunit 5

4

5

High-throughput

0.691

High

1112839

CUL2
Cullin-2

3

14

High-throughput

0.671

High

1139898

CSN3
COP9 signalosome complex subunit 3

3

4

High-throughput

0.650

High

1139891

ELOB
Elongin-B

3

2

High-throughput

0.633

High

167900

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

Small-scale

0.618

High

177875

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

8

Small-scale

0.618

High

1139890

ELOC
Elongin-C

2

3

High-throughput

0.571

High

983809

RBX1
E3 ubiquitin-protein ligase RBX1

1

4

High-throughput

0.479

High

1139892

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1139896

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

293708

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

1139897

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.458

High

64869

RCCD1
RCC1 domain-containing protein 1

1

4

High-throughput

0.445

High

638418

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.445

High

958640

CSN2
COP9 signalosome complex subunit 2

1

3

High-throughput

0.445

High

996955

TBA4A
Tubulin alpha-4A chain

1

8

High-throughput

0.445

High

1094338

CSN1
COP9 signalosome complex subunit 1

1

2

High-throughput

0.445

High

105961

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

248875

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

1139894

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.426

High

424302

INHA
Inhibin alpha chain

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025