Protein: DOCK8
Dedicator of cytokinesis protein 8

Gene: DOCK8
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q8NF50

Gene Ontology (top 5):
GO:0001771 - immunological synapse formation
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1244073

DOCK7
Dedicator of cytokinesis protein 7

7

11

High-throughput

0.965

High

1244070

DOCK6
Dedicator of cytokinesis protein 6

3

11

High-throughput

0.871

High

894226

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.757

High

1244090

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

7

12

High-throughput

0.749

High

1244072

LRCH3
DISP complex protein LRCH3

6

12

High-throughput

0.738

High

1244062

DOCK8
Dedicator of cytokinesis protein 8

1

11

High-throughput

0.698

High

264512

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

4

12

High-throughput

0.696

High

169109

ARPC3
Actin-related protein 2/3 complex subunit 3

3

1

High-throughput

0.667

High

1138572

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

5

12

High-throughput

0.657

High

838146

MEOX2
Homeobox protein MOX-2

2

1

High-throughput

0.633

High

1244065

APBP2
Amyloid protein-binding protein 2

2

1

High-throughput

0.628

High

925448

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.621

High

1244083

FXL12
F-box/LRR-repeat protein 12

2

0

High-throughput

0.618

High

348804

RASN
GTPase NRas

1

13

High-throughput

0.618

High

349503

RASH
GTPase HRas

1

10

High-throughput

0.618

High

350368

RASK
GTPase KRas

1

14

High-throughput

0.618

High

1244080

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1244085

CPNE7
Copine-7

2

0

High-throughput

0.602

High

1185489

MOB1B
MOB kinase activator 1B

2

11

High-throughput

0.584

High

1244079

MOB1A
MOB kinase activator 1A

2

11

High-throughput

0.584

High

253114

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1149239

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.573

High

334247

LDHA
L-lactate dehydrogenase A chain

2

3

High-throughput

0.571

High

396766

S10A8
Protein S100-A8

2

4

High-throughput

0.571

High

416478

S10A9
Protein S100-A9

2

5

High-throughput

0.571

High

422064

LDHB
L-lactate dehydrogenase B chain

2

3

High-throughput

0.571

High

427623

ANXA2
Annexin A2

2

4

High-throughput

0.571

High

430270

PROF1
Profilin-1

2

3

High-throughput

0.571

High

436103

ANXA6
Annexin A6

2

4

High-throughput

0.571

High

444915

ANXA5
Annexin A5

2

4

High-throughput

0.571

High

518895

TPR
Nucleoprotein TPR

2

4

High-throughput

0.571

High

519237

KCRB
Creatine kinase B-type

2

1

High-throughput

0.571

High

607115

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

1

High-throughput

0.571

High

627307

MCM3
DNA replication licensing factor MCM3

2

1

High-throughput

0.571

High

678478

S10A7
Protein S100-A7

2

5

High-throughput

0.571

High

713562

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

1

High-throughput

0.571

High

726319

BASI
Basigin

2

2

High-throughput

0.571

High

741892

TAGL2
Transgelin-2

2

6

High-throughput

0.571

High

763354

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

2

1

High-throughput

0.571

High

814998

LEG7
Galectin-7

2

1

High-throughput

0.571

High

924081

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

1

High-throughput

0.571

High

984628

CALD1
Caldesmon

2

3

High-throughput

0.571

High

993978

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

2

High-throughput

0.571

High

1244076

SRSF8
Serine/arginine-rich splicing factor 8

2

2

High-throughput

0.571

High

1244087

MAGD2
Melanoma-associated antigen D2

2

2

High-throughput

0.571

High

208850

CHM2A
Charged multivesicular body protein 2a

1

0

High-throughput

0.549

High

1046897

BYST
Bystin

1

0

High-throughput

0.549

High

1062320

RTP5
Receptor-transporting protein 5

1

0

High-throughput

0.549

High

1244081

EXOS5
Exosome complex component RRP46

1

0

High-throughput

0.549

High

1244082

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

High-throughput

0.549

High

1244092

CHSP1
Calcium-regulated heat-stable protein 1

1

0

High-throughput

0.549

High

127323

IPO5
Importin-5

2

0

High-throughput

0.547

High

340494

PGK1
Phosphoglycerate kinase 1

2

0

High-throughput

0.547

High

390386

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.547

High

391032

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.547

High

403289

LA
Lupus La protein

2

0

High-throughput

0.547

High

603206

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

2

0

High-throughput

0.547

High

606456

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

2

0

High-throughput

0.547

High

607696

NDKB
Nucleoside diphosphate kinase B

2

0

High-throughput

0.547

High

670981

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

2

0

High-throughput

0.547

High

816046

ATPO
ATP synthase subunit O, mitochondrial

2

0

High-throughput

0.547

High

888196

TPIS
Triosephosphate isomerase

2

0

High-throughput

0.547

High

901394

CH10
10 kDa heat shock protein, mitochondrial

2

0

High-throughput

0.547

High

1028739

SRSF5
Serine/arginine-rich splicing factor 5

2

0

High-throughput

0.547

High

1080958

SEPT7
Septin-7

2

0

High-throughput

0.547

High

1244063

TM263
Transmembrane protein 263

2

0

High-throughput

0.547

High

1244067

LRC59
Leucine-rich repeat-containing protein 59

2

0

High-throughput

0.547

High

1244088

PA2G4
Proliferation-associated protein 2G4

2

0

High-throughput

0.547

High

324509

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.536

High

1216612

CRLF3
Cytokine receptor-like factor 3

1

2

High-throughput

0.536

High

1244066

FAN
Protein FAN

1

2

High-throughput

0.536

High

1244074

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

355111

HBAZ
Hemoglobin subunit zeta

1

1

High-throughput

0.523

High

1244084

ZN581
Zinc finger protein 581

1

1

High-throughput

0.523

High

536402

GLU2B
Glucosidase 2 subunit beta

2

1

High-throughput

0.521

High

623963

THIL
Acetyl-CoA acetyltransferase, mitochondrial

2

1

High-throughput

0.521

High

671874

PDIA3
Protein disulfide-isomerase A3

2

2

High-throughput

0.521

High

975695

LMNB2
Lamin-B2

2

2

High-throughput

0.521

High

241702

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

0

High-throughput

0.513

High

1244075

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.513

High

1078591

SMAD2
Mothers against decapentaplegic homolog 2

1

4

High-throughput

0.508

High

827814

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.493

High

1244069

RM38
Large ribosomal subunit protein mL38

1

1

High-throughput

0.481

High

150603

ABLM1
Actin-binding LIM protein 1

1

1

High-throughput

0.479

High

160669

AURKA
Aurora kinase A

1

5

High-throughput

0.479

High

163018

XPO1
Exportin-1

1

3

High-throughput

0.479

High

433903

LYN
Tyrosine-protein kinase Lyn

1

7

Small-scale

0.479

High

523071

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

Small-scale

0.479

High

684892

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

970814

DSG1
Desmoglein-1

1

1

High-throughput

0.479

High

1043462

CUL4B
Cullin-4B

1

5

High-throughput

0.479

High

1244068

OPTN
Optineurin

1

6

High-throughput

0.479

High

1244086

MYO6
Unconventional myosin-VI

1

3

High-throughput

0.479

High

66724

A8K900
Mitochondrial GTPase 1

1

1

High-throughput

0.470

High

70389

B2R894
Large ribosomal subunit protein mL38

1

1

High-throughput

0.470

High

102387

G3V1X1
Proline/serine-rich coiled-coil 2, isoform CRA_a

1

1

High-throughput

0.470

High

1151135

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

451504

CLCA
Clathrin light chain A

1

0

High-throughput

0.458

High

614390

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.458

High

911901

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

1123635

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

1244064

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1244089

RUVB1
RuvB-like 1

1

0

High-throughput

0.458

High

1052828

FAK2
Protein-tyrosine kinase 2-beta

1

9

Small-scale

0.445

High

1160707

CSAG1
Chondrosarcoma-associated gene 1 protein

1

3

High-throughput

0.445

High

230401

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.439

High

1048710

DGCR6
Protein DGCR6

1

1

High-throughput

0.439

High

1244078

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.439

High

440628

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.437

High

1074182

SF3A1
Splicing factor 3A subunit 1

1

2

High-throughput

0.437

High

1244096

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

1244095

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

3

High-throughput

0.407

High

831503

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

1244093

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

1107910

F161A
Protein FAM161A

1

0

High-throughput

0.299

High

1200950

F124A
Protein FAM124A

1

0

High-throughput

0.299

High

1244071

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.299

High

262890

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.298

High

452836

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

2

0

High-throughput

0.298

High

594932

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

2

0

High-throughput

0.298

High

873457

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

0

High-throughput

0.298

High

1133897

RM02
Large ribosomal subunit protein uL2m

2

0

High-throughput

0.298

High

1244094

LC7L2
Putative RNA-binding protein Luc7-like 2

2

0

High-throughput

0.298

High

1244077

PIMRE
Protein PIMREG

1

0

High-throughput

0.282

High

1049431

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.279

Low

442322

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

1244091

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.249

Low

135272

E2F3
Transcription factor E2F3

1

0

Small-scale

0.232

Low

1169459

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024