Protein: SH3B4
SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein)

Gene: SH3B4, SH3BP4
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q9P0V3

Gene Ontology (top 5):
GO:0005092 - GDP-dissociation inhibitor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005905 - clathrin-coated pit
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167659

GIPC1
PDZ domain-containing protein GIPC1

4

1

Small-scale

0.913

High

1353631

GIPC2
PDZ domain-containing protein GIPC2

3

1

High-throughput

0.861

High

1157096

NTRK3
NT-3 growth factor receptor

2

1

High-throughput

0.811

High

896911

DYN2
Dynamin-2

2

1

Small-scale

0.776

High

966959

1433G
14-3-3 protein gamma

8

14

Small-scale

0.753

High

730304

1433B
14-3-3 protein beta/alpha

6

14

Small-scale

0.729

High

1049851

1433F
14-3-3 protein eta

5

14

Small-scale

0.718

High

691493

1433T
14-3-3 protein theta

5

14

Small-scale

0.716

High

1437921

PKHA1
Pleckstrin homology domain-containing family A member 1

1

0

High-throughput

0.702

High

972080

1433E
14-3-3 protein epsilon

4

2

Small-scale

0.696

High

990811

1433Z
14-3-3 protein zeta/delta

4

14

Small-scale

0.686

High

1453490

ARHGC
Rho guanine nucleotide exchange factor 12

1

0

High-throughput

0.678

High

839839

EPS15
Epidermal growth factor receptor substrate 15

3

1

Small-scale

0.656

High

1454066

SH3B4
SH3 domain-binding protein 4

1

0

Small-scale

0.631

High

1405195

MPP8
M-phase phosphoprotein 8

1

0

High-throughput

0.622

High

1050720

DYN1
Dynamin-1

1

1

Small-scale

0.618

High

1401123

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

1

High-throughput

0.618

High

1454074

ALK
ALK tyrosine kinase receptor

1

1

High-throughput

0.618

High

1454077

VSIG4
V-set and immunoglobulin domain-containing protein 4

3

1

High-throughput

0.609

High

1086191

CETN1
Centrin-1

2

0

High-throughput

0.602

High

730928

1433S
14-3-3 protein sigma

2

14

Small-scale

0.601

High

159893

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.586

High

208743

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.586

High

269624

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.586

High

463809

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.586

High

1216099

SPD2A
SH3 and PX domain-containing protein 2A

1

0

High-throughput

0.586

High

1309256

KSR1
Kinase suppressor of Ras 1

1

0

High-throughput

0.586

High

1402221

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.586

High

978364

RHOB
Rho-related GTP-binding protein RhoB

2

9

High-throughput

0.584

High

390792

TFR1
Transferrin receptor protein 1

1

0

Small-scale

0.576

High

1257047

SYDE1
Rho GTPase-activating protein SYDE1

1

1

High-throughput

0.553

High

1353292

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.553

High

1396838

SNX27
Sorting nexin-27

1

1

High-throughput

0.553

High

1454072

CIZ1
Cip1-interacting zinc finger protein

1

0

High-throughput

0.549

High

564480

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

1454073

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.530

High

1229905

AN34A
Ankyrin repeat domain-containing protein 34A

1

0

High-throughput

0.517

High

1454076

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.517

High

292763

RENR
Renin receptor

1

0

High-throughput

0.513

High

373361

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.513

High

1022980

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

610922

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.508

High

882199

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.508

High

431616

AP2A
Transcription factor AP-2-alpha

1

0

Small-scale

0.493

High

1208905

H2B2F
Histone H2B type 2-F

1

0

High-throughput

0.493

High

1133846

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

2

High-throughput

0.489

High

156362

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.486

High

215356

TXNL1
Thioredoxin-like protein 1

1

0

High-throughput

0.486

High

535616

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.486

High

681059

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.486

High

1038715

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

0

High-throughput

0.486

High

1358962

DNJA4
DnaJ homolog subfamily A member 4

1

0

High-throughput

0.486

High

1454075

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

0

High-throughput

0.486

High

376040

RASK
GTPase KRas

1

1

High-throughput

0.479

High

466504

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

581344

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

601475

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.479

High

941851

ARL4C
ADP-ribosylation factor-like protein 4C

1

3

High-throughput

0.479

High

953724

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

955696

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

962579

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

975288

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

988779

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

1015145

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.479

High

1015870

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

1140964

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1151910

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

1271028

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.479

High

1326519

ARL14
ADP-ribosylation factor-like protein 14

1

2

High-throughput

0.479

High

1367457

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1396648

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.479

High

1410261

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1433552

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.479

High

1438209

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.479

High

1447271

KI13B
Kinesin-like protein KIF13B

1

1

High-throughput

0.479

High

1405811

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.464

High

791790

SYUA
Alpha-synuclein

1

0

High-throughput

0.460

High

176885

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.458

High

189889

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

252182

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

487837

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

604249

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

719271

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

877026

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.458

High

901634

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

1004222

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1025599

CDK16
Cyclin-dependent kinase 16

1

0

High-throughput

0.458

High

1041338

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1045854

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1134071

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1145144

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1255883

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1289324

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1352616

DEN1A
DENN domain-containing protein 1A

1

0

High-throughput

0.458

High

1381985

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.458

High

1400871

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1452545

FA53C
Protein FAM53C

1

0

High-throughput

0.458

High

1454068

TES
Testin

1

0

High-throughput

0.458

High

1454070

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

1454071

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1454078

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

126846

RHOD
Rho-related GTP-binding protein RhoD

1

11

High-throughput

0.437

High

910234

RND2
Rho-related GTP-binding protein RhoN

1

11

High-throughput

0.437

High

962846

RND3
Rho-related GTP-binding protein RhoE

1

12

High-throughput

0.437

High

1187590

AR13B
ADP-ribosylation factor-like protein 13B

1

2

High-throughput

0.437

High

1349479

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1366897

RND1
Rho-related GTP-binding protein Rho6

1

12

High-throughput

0.437

High

1227602

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1133855

KI2S5
Killer cell immunoglobulin-like receptor 2DS5

1

1

High-throughput

0.407

High

888489

TSP3
Thrombospondin-3

3

0

High-throughput

0.347

High

1128965

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

1310800

CUL9
Cullin-9

2

0

High-throughput

0.318

High

1433280

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

2

0

High-throughput

0.305

High

1339470

TOIP2
Torsin-1A-interacting protein 2

2

0

High-throughput

0.288

High

1142535

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

1206968

CEP78
Centrosomal protein of 78 kDa

1

0

High-throughput

0.265

Low

1215657

ZBT37
Zinc finger and BTB domain-containing protein 37

1

0

High-throughput

0.265

Low

1217455

GKAP1
G kinase-anchoring protein 1

1

0

High-throughput

0.265

Low

1328470

CMIP6
Ciliary microtubule inner protein 6

1

0

High-throughput

0.265

Low

1416315

PRR14
Proline-rich protein 14

1

0

High-throughput

0.265

Low

1450238

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.265

Low

281441

GGYF1
GRB10-interacting GYF protein 1

1

0

High-throughput

0.249

Low

845836

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.249

Low

954661

GPR85
Probable G-protein coupled receptor 85

1

0

High-throughput

0.249

Low

1159880

OCLN
Occludin

1

0

High-throughput

0.249

Low

1187142

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.249

Low

1253002

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1360406

SRS12
Serine/arginine-rich splicing factor 12

1

0

High-throughput

0.249

Low

1432986

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.249

Low

1454067

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.249

Low

1454069

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025