Protein: TYOBP
TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)

Gene: TYOBP, TYROBP
Organism: Homo sapiens
Interactions: 105
UniProt ID: O43914

Gene Ontology (top 5):
GO:0002222 - stimulatory killer cell immunoglobulin-like receptor signaling pathway
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002228 - natural killer cell mediated immunity
GO:0002274 - myeloid leukocyte activation
GO:0002282 - microglial cell activation involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

230935

NCTR2
Natural cytotoxicity triggering receptor 2

2

9

Small-scale

0.601

High

231016

TREM1
Triggering receptor expressed on myeloid cells 1

2

9

Small-scale

0.601

High

230944

KSYK
Tyrosine-protein kinase SYK

2

1

Small-scale

0.595

High

128547

SIRB1
Signal-regulatory protein beta-1

2

0

Small-scale

0.585

High

230941

NKG2C
NKG2-C type II integral membrane protein

2

3

Small-scale

0.584

High

230946

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

2

3

Small-scale

0.584

High

231021

TREM2
Triggering receptor expressed on myeloid cells 2

2

0

Small-scale

0.583

High

230988

TM86A
Lysoplasmalogenase TMEM86A

2

0

High-throughput

0.580

High

230940

ITB8
Integrin beta-8

2

0

High-throughput

0.576

High

230958

CD47
Leukocyte surface antigen CD47

2

0

High-throughput

0.576

High

230964

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

2

0

High-throughput

0.576

High

230966

PAR14
Protein mono-ADP-ribosyltransferase PARP14

2

0

High-throughput

0.576

High

230969

ODR4
Protein odr-4 homolog

2

0

High-throughput

0.576

High

230980

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

0

High-throughput

0.576

High

230985

LRC8A
Volume-regulated anion channel subunit LRRC8A

2

0

High-throughput

0.576

High

230996

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

2

0

High-throughput

0.576

High

230999

F241B
Protein FAM241B

2

0

High-throughput

0.576

High

231003

PANX1
Pannexin-1

2

0

High-throughput

0.576

High

231005

SEC62
Translocation protein SEC62

2

0

High-throughput

0.576

High

230931

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

Small-scale

0.554

High

230997

S35B4
Nucleotide sugar transporter SLC35B4

2

1

High-throughput

0.553

High

231011

TMX4
Thioredoxin-related transmembrane protein 4

2

1

High-throughput

0.549

High

231012

TMX1
Thioredoxin-related transmembrane protein 1

2

1

High-throughput

0.549

High

230938

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.536

High

230939

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

1

High-throughput

0.536

High

230947

DYN2
Dynamin-2

1

2

High-throughput

0.536

High

230948

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

1

High-throughput

0.536

High

230950

AT12A
Potassium-transporting ATPase alpha chain 2

1

1

High-throughput

0.536

High

230954

DYN1
Dynamin-1

1

2

High-throughput

0.536

High

230993

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.536

High

231013

AT133
Polyamine-transporting ATPase 13A3

1

4

High-throughput

0.536

High

231014

AT131
Endoplasmic reticulum transmembrane helix translocase

1

3

High-throughput

0.536

High

231025

DYN3
Dynamin-3

1

2

High-throughput

0.536

High

230962

KI2S5
Killer cell immunoglobulin-like receptor 2DS5

1

3

Small-scale

0.534

High

194797

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.513

High

230932

HIP1R
Huntingtin-interacting protein 1-related protein

1

0

High-throughput

0.513

High

230934

WFS1
Wolframin

1

0

High-throughput

0.513

High

230949

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.513

High

230951

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.513

High

230952

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

230953

TAP2
Antigen peptide transporter 2

1

0

High-throughput

0.513

High

230963

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.513

High

230970

TBC9B
TBC1 domain family member 9B

1

0

High-throughput

0.513

High

230973

TTI2
TELO2-interacting protein 2

1

0

High-throughput

0.513

High

230974

CNNM4
Metal transporter CNNM4

1

0

High-throughput

0.513

High

230977

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.513

High

230979

DYM
Dymeclin

1

0

High-throughput

0.513

High

230983

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.513

High

230984

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.513

High

230990

S15A4
Solute carrier family 15 member 4

1

0

Small-scale

0.513

High

230992

VANG1
Vang-like protein 1

1

0

High-throughput

0.513

High

231000

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

0

High-throughput

0.513

High

231002

INT4
Integrator complex subunit 4

1

0

High-throughput

0.513

High

231004

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.513

High

231006

SMAD5
Mothers against decapentaplegic homolog 5

1

0

High-throughput

0.513

High

231007

CIB1
Calcium and integrin-binding protein 1

1

0

High-throughput

0.513

High

231009

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.513

High

231020

F118A
Protein FAM118A

1

0

High-throughput

0.513

High

231001

RN185
E3 ubiquitin-protein ligase RNF185

1

1

High-throughput

0.489

High

69607

CLM7
CMRF35-like molecule 7

1

9

Small-scale

0.479

High

188583

SIGL5
Sialic acid-binding Ig-like lectin 5

1

1

Small-scale

0.479

High

230945

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

1

3

Small-scale

0.479

High

230957

CLM6
CMRF35-like molecule 6

1

9

Small-scale

0.479

High

230959

SIG14
Sialic acid-binding Ig-like lectin 14

1

1

Small-scale

0.479

High

230960

KLRD1
Natural killer cells antigen CD94

1

3

Small-scale

0.479

High

230961

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

3

Small-scale

0.479

High

230975

CLM5
CMRF35-like molecule 5

1

10

Small-scale

0.479

High

3183

CD3CH
Protein CD300H

1

9

Small-scale

0.445

High

230986

WDFY3
WD repeat and FYVE domain-containing protein 3

1

1

High-throughput

0.445

High

178873

SCAM2
Secretory carrier-associated membrane protein 2

1

0

High-throughput

0.426

High

230937

ITAV
Integrin alpha-V

1

0

High-throughput

0.426

High

230955

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.426

High

230978

UN13D
Protein unc-13 homolog D

1

0

High-throughput

0.426

High

230987

GHDC
GH3 domain-containing protein

1

0

High-throughput

0.426

High

230995

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.426

High

230998

PMEPA
Protein TMEPAI

1

0

High-throughput

0.426

High

231017

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.426

High

231026

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.426

High

230943

ZAP70
Tyrosine-protein kinase ZAP-70

1

1

Small-scale

0.408

High

230967

MBRL
Membralin

2

0

High-throughput

0.313

High

230981

NOP9
Nucleolar protein 9

2

0

High-throughput

0.313

High

230982

RETR3
Reticulophagy regulator 3

2

0

High-throughput

0.313

High

230933

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.279

Low

230942

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.279

Low

230956

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low

230965

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

0

High-throughput

0.279

Low

230968

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

0

High-throughput

0.279

Low

230971

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

230976

THADA
tRNA

1

0

High-throughput

0.279

Low

230994

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

231008

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

0

High-throughput

0.279

Low

231010

TSYL1
Testis-specific Y-encoded-like protein 1

1

0

High-throughput

0.279

Low

231015

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

231018

PYRG2
CTP synthase 2

1

0

High-throughput

0.279

Low

231019

UFSP2
Ufm1-specific protease 2

1

0

High-throughput

0.279

Low

231022

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.279

Low

231023

EXTL2
Exostosin-like 2

1

0

High-throughput

0.279

Low

231028

TNPO3
Transportin-3

1

0

High-throughput

0.279

Low

230936

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

0

High-throughput

0.232

Low

230972

TRI68
E3 ubiquitin-protein ligase TRIM68

1

0

High-throughput

0.232

Low

230989

MACOI
Macoilin

1

0

High-throughput

0.232

Low

230991

MROH1
Maestro heat-like repeat-containing protein family member 1

1

0

High-throughput

0.232

Low

231024

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

0

High-throughput

0.232

Low

231027

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025